4(1H)-Quinolinone, 6-methoxy-7-[3-(4-morpholinyl)propoxy]-

Base Information

• Chemical Name: 4(1H)-Quinolinone, 6-methoxy-7-[3-(4-morpholinyl)propoxy]-
• CAS No.: 205448-38-0
• Molecular Formula: C₁₇H₂₂N₂O₄
• Molecular Weight: 318.373

Synonyms:6-Methoxy-7-(3-morpholinopropoxy)quinolin-4-ol;6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4(1H)-quinolinone

Chemical Property of 4(1H)-Quinolinone, 6-methoxy-7-[3-(4-morpholinyl)propoxy]-

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4(1H)-Quinolinone, 6-methoxy-7-[3-(4-morpholinyl)propoxy]-

There total 16 articles about 4(1H)-Quinolinone, 6-methoxy-7-[3-(4-morpholinyl)propoxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%

morpholine (110-91-8,99108-56-2) + 6-methyloxy-7-(4-(3-chloropropoxy))-4-4-hydroxyquinoline (1394166-09-6,1428788-16-2) → 6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-ol, sodium salt (1167053-13-5,205448-38-0)

Guidance literature:

In acetonitrile; at 85 ℃; for 10h;

DOI:10.1016/j.bmc.2013.04.013

Reference yield: 93.7%

morpholine (110-91-8,99108-56-2) + 7-(3-chloropropyloxy)-6-methoxy-4(1H)-quinolinone (1394166-09-6,1428788-16-2) → 6-methoxy-7-[3-(morpholin-4-yl)propoxy]-4(1H)-quinolinone (1167053-13-5,205448-38-0)

Guidance literature:

In acetonitrile; for 8h; Reflux;

Reference yield: 41.0%

5-((3-(3-morpholinopropoxy)-4-methoxyanilino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione (205448-37-9) → 6-methoxy-7-[3-(morpholin-4-yl)propoxy]-4(1H)-quinolinone (1167053-13-5,205448-38-0)

Guidance literature:

In diphenylether; for 0.0333333h; Heating / reflux;

upstream raw materials:

5-((3-(3-morpholinopropoxy)-4-methoxyanilino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione

1-[4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl]ethan-1-one

1-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-3-(dimethylamino)propyl-2-en-1-one

morpholine

Downstream raw materials:

4-chloro-6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinoline

4-(3-((4-(2-fluoro-4-nitrophenoxy)-6-methoxyquinolin-7-yl)oxy)propyl)morpholine

3-Fluoro-4-{[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy}-aniline

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