YIL 781

Base Information

• Chemical Name: YIL 781
• CAS No.: 875258-85-8
• Molecular Formula: C₂₄H₂₈FN₃O₂
• Molecular Weight: 409.504
• Mol file: 875258-85-8.mol

Synonyms:6-(4-fluorophenoxy)-3-[[(3S)-1-isopropyl-3-piperidyl]methyl]-2-methyl-quinazolin-4-one hydrochloride; YIL781

Chemical Property of YIL 781

Chemical Property:

• PSA: 47.36000
• LogP: 5.49660
• Storage Temp.: room temp
• Solubility.: H2O: soluble2mg/mL, clear (warmed)

Purity/Quality:

99% ^*data from raw suppliers

YIL781 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: YIL 781 is a ghrelin receptor antagonist useful in the treatment of obesity and diabetes.

Technology Process of YIL 781

There total 3 articles about YIL 781 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

6-bromo-3-{[(3S)-isopropylpiperidin-3-yl]methyl}-2-methylquinazolin-4(3H)-one (875269-75-3) + 4-Fluorophenol (371-41-5) → YIL-781 (875258-85-8)

Guidance literature:

With 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate; copper(l) chloride; In 1-methyl-pyrrolidin-2-one; at 205 ℃; for 0.333333h; microwave irradiation;

DOI:10.1021/jm070071+

Reference yield:

2-iodo-propane (75-30-9) + 4-Fluorophenol (371-41-5) + C20H26BrN3O3 → 6-(4-fluorophenoxy)-3-[(1-isopropylpiperidin-3-yl)methyl]-2-methylquinazolin-4(3H)-one (875258-85-8)

Guidance literature:

C₂₀H₂₆BrN₃O₃; With trifluoroacetic acid;

2-iodo-propane; With potassium carbonate;

4-Fluorophenol; With copper(l) iodide; caesium carbonate;

Reference yield:

→ 6-(4-fluorophenoxy)-3-[(1-isopropylpiperidin-3-yl)methyl]-2-methylquinazolin-4(3H)-one (875258-85-8)

Guidance literature:

upstream raw materials:

6-bromo-3-{[(3S)-isopropylpiperidin-3-yl]methyl}-2-methylquinazolin-4(3H)-one

4-Fluorophenol

2-iodo-propane

Refernces

• 1、 Rudolph, Joachim,Esler, William P.,O'Connor, Stephen,Coish, Philip D. G.,Wickens, Philip L.,Brands, Michael,Bierer, Donald E.,Bloomquist, Brian T.,Bondar, Georgiy,Chen, Libing,Chuang, Chih-Yuan,Claus, Thomas H.,Fathi, Zahra,Fu, Wenlang,Khire, Uday R.,Kristie, James A.,Liu, Xiao-Gao,Lowe, Derek B.,McClure, Andrea C.,Michels, Martin,Ortiz, Astrid A.,Ramsden, Philip D.,Schoenleber, Robert W.,Shelekhin, Tatiana E.,Vakalopoulos, Alexandras,Tang, Weifeng,Wang, Lei,Yi, Lin,Gardell, Stephen J.,Livingston, James N.,Sweet, Laurel J.,Bullock, William H.. "Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity". . p. 5202 - 5216. Retrieved 2008/03/12.