Synonyms:2-iodopropane;isopropyl iodide
99% *data from raw suppliers
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Xn:Harmful;There total 80 articles about 2-Iodopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield: 18.0%
Reference yield:
Reference yield:
The study investigates the asymmetric alkylation of arylacetic acid derivatives using binaphthyl esters as chiral auxiliaries. The researchers, Kaoru Fuji and colleagues, focused on synthesizing optically active 2-arylalkanoic acids, which are important due to their biological activity. They used (R)-binaphthyl esters of substituted and unsubstituted phenylacetic acids and alkylated them with various alkylating agents such as isopropyl iodide and isobutyl iodide. The reactions were carried out in tetrahydrofuran (THF) with lithium diisopropylamide (LDA) and hexamethylphosphoric triamide (HMPA) as reagents. The study demonstrated high diastereoselectivity, with the bulkiness of the alkylating agents significantly influencing the stereoselectivity. The phenolic hydroxyl group in the binaphthyl esters was found to be crucial for achieving high diastereoselectivity. The researchers also explored the effects of different substituents and reaction conditions on the yield and diastereomeric ratios of the products. The study provides insights into the mechanism of the reaction and its potential applications in the synthesis of biologically active compounds.
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