6-Methyl-quinazoline-2,4-diamine

Base Information

• Chemical Name: 6-Methyl-quinazoline-2,4-diamine
• CAS No.: 1955-61-9
• Molecular Formula: C₉H₁₀N₄
• Molecular Weight: 174.205
• Hs Code.: 2933990090
• Mol file: 1955-61-9.mol

Synonyms:Quinazoline,2,4-diamino-6-methyl- (6CI,7CI,8CI); 2,4-Diamino-6-methylquinazoline;6-Methyl-2,4-quinazolinediamine; NSC 403380

Chemical Property of 6-Methyl-quinazoline-2,4-diamine

Chemical Property:

• Vapor Pressure: 1.09E-08mmHg at 25°C
• Boiling Point: 461.2°Cat760mmHg
• Flash Point: 263.7°C
• PSA: 77.82000
• Density: 1.331g/cm³
• LogP: 2.26500

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,4-Diamino-6-methylquinazoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Methyl-quinazoline-2,4-diamine

There total 7 articles about 6-Methyl-quinazoline-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

2-amino-5-methylbenzonitrile (5925-93-9) + N-Cyanoguanidine (127099-85-8,780722-26-1,461-58-5) → 6-methyl-2,4-quinazolinediamine (1955-61-9)

Guidance literature:

With hydrogenchloride; for 1.5h; Heating;

DOI:10.1002/jhet.5570240210

Reference yield: 57.0%

2-bromo-5-methylbenzylnitrile (42872-83-3) + guanidine hydrochloride (50-01-1) → 6-methyl-2,4-quinazolinediamine (1955-61-9)

Guidance literature:

2-bromo-5-methylbenzylnitrile; guanidine hydrochloride; With potassium carbonate; N,N`-dimethylethylenediamine; In N,N-dimethyl-formamide; for 0.25h; Inert atmosphere;

With copper(l) iodide; In N,N-dimethyl-formamide; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.1055/S-0029-1218530

Reference yield: 54.0%

guanidine carbonate (593-85-1,90332-86-8,3425-08-9) + 2-fluoro-5-methylbenzonitrile (64113-84-4) → 6-methyl-2,4-quinazolinediamine (1955-61-9)

Guidance literature:

In N,N-dimethyl acetamide; at 140 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.bmcl.2014.11.004

upstream raw materials:

2-amino-5-methylbenzonitrile

N-Cyanoguanidine

2-nitro-5-methylbenzonitrile

2-chloro-4-methyl-1-nitrobenzene

Downstream raw materials:

6-<<(4-fluorophenyl)methylamino>methyl>-2,4-quinazolinediamine

6-<<(4-bromophenyl)methylamino>methyl>-2,4-quinazolinediamine

6-{[(3-Chloro-phenyl)-methyl-amino]-methyl}-quinazoline-2,4-diamine

6-[(Ethyl-p-tolyl-amino)-methyl]-quinazoline-2,4-diamine

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