(2R,4S,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic acid

Base Information

Chemical Name:(2R,4S,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic acid
CAS No.:155396-69-3
Molecular Formula:C22H25NO6
Molecular Weight:399.444
Hs Code.:
European Community (EC) Number:605-008-3
DSSTox Substance ID:DTXSID00431350
Nikkaji Number:J582.836H
Wikidata:Q76414505
Mol file:155396-69-3.mol

Synonyms:155396-69-3;(2R,4S,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic acid;(2R,4S,5R)-2-(4-methoxyphenyl)-3-[(2-methylpropan-2-yl)oxycarbonyl]-4-phenyl-1,3-oxazolidine-5-carboxylic acid;MFCD24387546;3,5-Oxazolidinedicarboxylic acid, 2-(4-methoxyphenyl)-4-phenyl-, 3-(1,1-dimethylethyl) ester, (2R,4S,5R)-;SCHEMBL2805332;DTXSID00431350;(2R,4S,5R)-3-Boc-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic Acid;AKOS022174994;AC-30908;AS-78653;CS-0447403;F12988;A883653;(2R,4S,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylicacid;2alpha-(4-Methoxyphenyl)-3-(tert-butoxycarbonyl)-4beta-phenyloxazolidine-5alpha-carboxylic acid

Suppliers and Price of (2R,4S,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(2R,4S,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylicacid 95+%
250mg
$ 452.00

Crysdot
(2R,4S,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylicacid 95+%
1g
$ 1131.00

Chemenu
(2R,4S,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylicacid 95%
1g
$ 1066.00

AK Scientific
(2R,4S,5R)-3-(Tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylicacid
5g
$ 2085.00

Total 40 raw suppliers

Chemical Property of (2R,4S,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic acid

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:573.799°C at 760 mmHg
PKA:2.99±0.60(Predicted)
Flash Point:300.823°C
PSA：85.30000
Density:1.238g/cm³
LogP:4.09350
Storage Temp.:2-8°C
XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:399.16818752
Heavy Atom Count:29
Complexity:574

Purity/Quality:

97% ^*data from raw suppliers

(2R,4S,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1C(C(OC1C2=CC=C(C=C2)OC)C(=O)O)C3=CC=CC=C3
Isomeric SMILES:CC(C)(C)OC(=O)N1[C@H]([C@@H](O[C@@H]1C2=CC=C(C=C2)OC)C(=O)O)C3=CC=CC=C3
Use Description (2R,4S,5R)-3-(tert-butoxycarbonyl)-2-(4-Methoxyphenyl)-4-phenyloxazolidine-5-carboxylic acid, a specific chemical compound, serves diverse functions across different fields. In the pharmaceutical and medicinal chemistry sector, it plays a pivotal role as a chiral building block in the synthesis of complex molecules, contributing to drug discovery and the development of potential therapeutic agents. In the field of organic chemistry, (2R,4S,5R)-3-(tert-butoxycarbonyl)-2-(4-Methoxyphenyl)-4-phenyloxazolidine-5-carboxylic acid can serve as a valuable intermediate in the creation of intricate molecular structures for research purposes. Moreover, in the study of chiral compounds and asymmetric synthesis, it may be employed to investigate stereochemistry and explore enantioselective reactions. Its applications in pharmaceuticals, organic synthesis, and chemical research underscore its significance in driving innovation, scientific exploration, and potential medical breakthroughs within these distinct domains.

Technology Process of (2R,4S,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic acid

There total 12 articles about (2R,4S,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 155396-68-2
(2R,4S,5R)-5-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-2-(4-methoxy-phenyl)-4-phenyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 155396-69-3
(2R,4S,5R)-(2R,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid

Guidance literature:: With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; 1.) 0 deg C, 30 min, 2.) 20 deg C, 2 h;
DOI:10.1021/jo00085a004

Reference yield: 94.5%

: 155396-69-3
(2R,4S,5R)-(2R,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid

Guidance literature:

Reference yield:

: 4248-19-5
tert-butyl carbazate

: 155396-69-3
(2R,4S,5R)-(2R,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 68 percent / HCOOH / methanol; H₂O / 21 h / 20 °C

2: 100 percent / K₂CO₃ / tetrahydrofuran / 12 h / Heating

3: 1.) LiN(Si(CH₃)3)2 / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 15 min

4: 90 percent / DDQ, 4 Angstroem molecular sieves / CH₂Cl₂ / 14 h / 20 °C

5: 100 percent / LiOH, H₂O₂ / tetrahydrofuran; H₂O / 1.) 0 deg C, 30 min, 2.) 20 deg C, 2 h

With lithium hydroxide; formic acid; 4 A molecular sieve; dihydrogen peroxide; potassium carbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jo00085a004