(9S)- 9-(PhenylMethoxy)-Cinchonan-6'-ol

Base Information

• Chemical Name: (9S)- 9-(PhenylMethoxy)-Cinchonan-6'-ol
• CAS No.: 761434-35-9
• Molecular Formula: C₂₆H₂₈N₂O₂
• Molecular Weight: 400.521
• Hs Code.: 2933990090
• Mol file: 761434-35-9.mol

Synonyms:(9S)- 9-(phenylMethoxy)-Cinchonan-6'-ol;Cinchonan-6'-ol, 9-(phenylmethoxy)-, (9S)-;4-((1S)-(Benzyloxy)((1S,2R,5R)-5-vinylquinuclidin-2-yl)methyl)quinolin-6-ol

Chemical Property of (9S)- 9-(PhenylMethoxy)-Cinchonan-6'-ol

Chemical Property:

• Boiling Point: 562.3±50.0 °C(Predicted)
• PKA: 8.77±0.40(Predicted)
• PSA: 45.59000
• Density: 1.23±0.1 g/cm3(Predicted)
• LogP: 5.03260

Purity/Quality:

98.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (9S)- 9-(PhenylMethoxy)-Cinchonan-6'-ol

There total 25 articles about (9S)- 9-(PhenylMethoxy)-Cinchonan-6'-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-((R)-(benzyloxy)(6-methoxyquinolin-4-yl)methyl)-5-vinylquinuclidine (345217-87-0) → 9-O-benzylcupreine (838821-39-9,761434-35-9)

Guidance literature:

With sodium thioethylate; In N,N-dimethyl-formamide; at 110 ℃; for 120h; Inert atmosphere;

DOI:10.1016/j.tet.2019.130816

Reference yield: 100.0%

9-O-benzylquinidine (345217-88-1) → 9-O-benzylcupreidine (761434-35-9)

Guidance literature:

With sodium thioethylate; In N,N-dimethyl-formamide; at 110 ℃; for 120h; Inert atmosphere;

DOI:10.1016/j.tet.2019.130816

Reference yield: 87.0%

quinidine 9-O-benzyl ether → BnCPD (761434-35-9)

Guidance literature:

With sodium thioethylate; In N,N-dimethyl-formamide; at 110 ℃;

DOI:10.1021/ja047281l

upstream raw materials:

quinindine

benzyl bromide

benzyl chloride

2-((R)-(benzyloxy)(6-methoxyquinolin-4-yl)methyl)-5-vinylquinuclidine