9-O-benzylquinine

Base Information

• Chemical Name: 9-O-benzylquinine
• CAS No.: 345217-87-0
• Molecular Formula: C₂₇H₃₀N₂O₂
• Molecular Weight: 414.547
• Mol file: 345217-87-0.mol

Synonyms:9-O-benzylquinine

Chemical Property of 9-O-benzylquinine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 9-O-benzylquinine

There total 5 articles about 9-O-benzylquinine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl chloride (100-44-7) + Quinine (130-95-0) → 2-((R)-(benzyloxy)(6-methoxyquinolin-4-yl)methyl)-5-vinylquinuclidine (345217-87-0)

Guidance literature:

Quinine; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;

benzyl chloride; In N,N-dimethyl-formamide; at 20 ℃; for 20h; Inert atmosphere;

DOI:10.1016/j.tet.2019.130816

Reference yield: 88.0%

benzyl bromide (100-39-0) + Quinine (130-95-0) → 2-((R)-(benzyloxy)(6-methoxyquinolin-4-yl)methyl)-5-vinylquinuclidine (345217-87-0)

Guidance literature:

Quinine; With potassium hydride; In tetrahydrofuran; at 0 - 50 ℃; for 1.16667h; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; at 20 ℃; for 2.16667h; Inert atmosphere;

DOI:10.1016/j.tetlet.2020.152552

Reference yield: 65.0%

→ 2-((R)-(benzyloxy)(6-methoxyquinolin-4-yl)methyl)-5-vinylquinuclidine (345217-87-0)

Guidance literature:

upstream raw materials:

benzyl chloride

Quinine

benzyl bromide

quinine

Downstream raw materials:

9-O-benzyl-6'-hydroxycinchonidine

9-O-benzyl-10,11-dihydro-11-methylaminoquinine