(R,R)-2-Iodo-1,3-bis[1-(MesitylcarbaMoyl)ethoxy]benzene

Base Information

• Chemical Name: (R,R)-2-Iodo-1,3-bis[1-(MesitylcarbaMoyl)ethoxy]benzene
• CAS No.: 1226896-38-3
• Molecular Formula: C30H35IN2O4
• Molecular Weight: 614.523
• Mol file: 1226896-38-3.mol

Synonyms:(R,R)-2-Iodo-1,3-bis[1-(2,4,6-trimethylphenylcarbamoyl)ethoxy]benzene;I0807;(R,R)-2-Iodo-1,3-bis[1-(mesitylcarbamoyl)ethoxy]benzene;(2R,2'R)-2,2'-([2-iodo-1,3-phenylene]bis(oxy))bis(N-mesitylpropanamide);

Chemical Property of (R,R)-2-Iodo-1,3-bis[1-(MesitylcarbaMoyl)ethoxy]benzene

Chemical Property:

• PSA: 83.64000
• LogP: 8.25260
• Storage Temp.: 0-10°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R,R)-2-Iodo-1,3-bis[1-(mesitylcarbamoyl)ethoxy]benzene >98.0%(HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R,R)-2-Iodo-1,3-bis[1-(MesitylcarbaMoyl)ethoxy]benzene

There total 7 articles about (R,R)-2-Iodo-1,3-bis[1-(MesitylcarbaMoyl)ethoxy]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(2R,2′R)-2,2′-((2-iodo-1,3-phenylene)bis(oxy))dipropanoic acid (1226896-33-8) + 2,4,6-trimethylaniline (88-05-1) → (2R,2'R)-2,2'-((2-iodo-1,3-phenylene)bis(oxy))bis(N-mesitylpropanamide) (1226896-38-3)

Guidance literature:

(2R,2′R)-2,2′-((2-iodo-1,3-phenylene)bis(oxy))dipropanoic acid; With thionyl chloride; for 1.5h; Reflux;

2,4,6-trimethylaniline; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201603022

Reference yield: 72.0%

(2R,2'R)-2,2'-((2-iodo-1,3-phenylene)bis(oxy))dipropanoyl chloride + 2,4,6-trimethylaniline (88-05-1) → (2R,2'R)-2,2'-((2-iodo-1,3-phenylene)bis(oxy))bis(N-mesitylpropanamide) (1226896-38-3)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/chem.202000927

Reference yield:

2-iodoresorcinol (41046-67-7) → (2R,2'R)-2,2'-((2-iodo-1,3-phenylene)bis(oxy))bis(N-mesitylpropanamide) (1226896-38-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide / tetrahydrofuran; water; methanol / 6 h / 20 °C

3.1: oxalyl dichloride / dichloromethane / 3 h / 20 °C / Inert atmosphere

3.2: 16 h / 20 °C / Inert atmosphere

With oxalyl dichloride; di-isopropyl azodicarboxylate; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1002/anie.201507180

upstream raw materials:

2,4,6-trimethylaniline

recorcinol

2-iodoresorcinol

(2R,2'R)-dimethyl 2,2'-((2-iodo-1,3-phenylene)bis(oxy))dipropanoate

Downstream raw materials:

(2,6-bis(((R)-1-(mesitylamino)-1-oxopropan-2-yl)oxy)-phenyl)-λ³-iodanediyl diacetate