(2S)- 2-aMino-N,3,3-triMethyl-N-(phenylMethyl)-ButanaMide

Base Information

Chemical Name:(2S)- 2-aMino-N,3,3-triMethyl-N-(phenylMethyl)-ButanaMide
CAS No.:947383-62-2
Molecular Formula:C14H22N2O
Molecular Weight:234.341
Hs Code.:
Mol file:947383-62-2.mol

Synonyms:(S)-t-leucine N-benzyl-N-methyl-amide;(S)-2-amino-n-benzyl-n,3,3-trimethylbutanamide;(2S)- 2-aMino-N,3,3-triMethyl-N-(phenylMethyl)-ButanaMide;Butanamide, 2-amino-N,3,3-trimethyl-N-(phenylmethyl)-, (2S)-;(2S)-2-Amino-N,3,3-trimethyl-N- (phenylmethyl)butanamide,99%e.e.;(2S)-2-Amino-N,3,3-trimethyl-N-(phenylmethyl)butanamide, 98%, (99% ee)

Suppliers and Price of (2S)- 2-aMino-N,3,3-triMethyl-N-(phenylMethyl)-ButanaMide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Strem Chemicals
(2S)-2-Amino-N,3,3-trimethyl-N-(phenylmethyl)butanamide, 98%, (99% ee) (99% ee)
100mg
$ 154.00

Arctom
(S)-2-Amino-N-benzyl-N,3,3-trimethylbutanamide 98%
100mg
$ 292.00

Total 10 raw suppliers

Chemical Property of (2S)- 2-aMino-N,3,3-triMethyl-N-(phenylMethyl)-ButanaMide

Chemical Property:

Boiling Point:358.3±35.0 °C (760 mmHg)
PSA：46.33000
Density:1.019±0.06 g/cm3(20 °C , 760mmHg)
LogP:2.71870

Purity/Quality:

97% ^*data from raw suppliers

(2S)-2-Amino-N,3,3-trimethyl-N-(phenylmethyl)butanamide, 98%, (99% ee) (99% ee) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2S)- 2-aMino-N,3,3-triMethyl-N-(phenylMethyl)-ButanaMide

There total 4 articles about (2S)- 2-aMino-N,3,3-triMethyl-N-(phenylMethyl)-ButanaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1032509-62-8
tert-butyl (S)-1-(N-benzyl-N-methylcarbamoyl)-2,2-dimethylpropylcarbamate

: 947383-62-2
(S)-t-leucine N-benzyl-N-methyl-amide

Guidance literature:: tert-butyl (S)-1-(N-benzyl-N-methylcarbamoyl)-2,2-dimethylpropylcarbamate; With trifluoroacetic acid; In dichloromethane; at 23 ℃; for 1h;

With sodium hydrogencarbonate; In dichloromethane; water; Saturated solution;
DOI:10.1016/j.tetasy.2008.09.030

Reference yield:

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 103-67-3
benzyl-methyl-amine

: 947383-62-2
(S)-t-leucine N-benzyl-N-methyl-amide

Guidance literature:: N-tert-butyloxycarbonyl-L-tert-leucine; benzyl-methyl-amine; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1.5h;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h; Further stages.;
DOI:10.1021/ja027246j

Reference yield:

: 103-67-3
benzyl-methyl-amine

: 947383-62-2
(S)-t-leucine N-benzyl-N-methyl-amide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2: trifluoroacetic acid / dichloromethane / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1002/anie.201600142