tert-butyl (S)-1-(N-benzyl-N-methylcarbamoyl)-2,2-dimethylpropylcarbamate

Base Information

• Chemical Name: tert-butyl (S)-1-(N-benzyl-N-methylcarbamoyl)-2,2-dimethylpropylcarbamate
• CAS No.: 1032509-62-8
• Molecular Formula: C₁₉H₃₀N₂O₃
• Molecular Weight: 334.459
• Mol file: 1032509-62-8.mol

Synonyms:tert-butyl (S)-1-(N-benzyl-N-methylcarbamoyl)-2,2-dimethylpropylcarbamate

Chemical Property of tert-butyl (S)-1-(N-benzyl-N-methylcarbamoyl)-2,2-dimethylpropylcarbamate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (S)-1-(N-benzyl-N-methylcarbamoyl)-2,2-dimethylpropylcarbamate

There total 1 articles about tert-butyl (S)-1-(N-benzyl-N-methylcarbamoyl)-2,2-dimethylpropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-tert-butyloxycarbonyl-L-tert-leucine (62965-35-9) + benzyl-methyl-amine (103-67-3) → tert-butyl (S)-1-(N-benzyl-N-methylcarbamoyl)-2,2-dimethylpropylcarbamate (1032509-62-8)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In chloroform; at 23 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.tetasy.2008.09.030

Reference yield: 88.0%

tert-butyl (S)-1-(N-benzyl-N-methylcarbamoyl)-2,2-dimethylpropylcarbamate (1032509-62-8) → (S)-t-leucine N-benzyl-N-methyl-amide (947383-62-2)

Guidance literature:

tert-butyl (S)-1-(N-benzyl-N-methylcarbamoyl)-2,2-dimethylpropylcarbamate; With trifluoroacetic acid; In dichloromethane; at 23 ℃; for 1h;

With sodium hydrogencarbonate; In dichloromethane; water; Saturated solution;

DOI:10.1016/j.tetasy.2008.09.030

Reference yield:

tert-butyl (S)-1-(N-benzyl-N-methylcarbamoyl)-2,2-dimethylpropylcarbamate (1032509-62-8) + 3,5-bistrifluoromethylphenylisothiocyanate (23165-29-9) → 1-((S)-1-(N-benzyl-N-methylcarbamoyl)-2,2-dimethylpropyl)-3-(3,5-bis(trifluoromethyl)phenyl)thiourea (959979-30-7)

Guidance literature:

tert-butyl (S)-1-(N-benzyl-N-methylcarbamoyl)-2,2-dimethylpropylcarbamate; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

3,5-bistrifluoromethylphenylisothiocyanate; With triethylamine; In dichloromethane; at 20 ℃; for 4h; Further stages.;

DOI:10.1021/ja801514m

upstream raw materials:

N-tert-butyloxycarbonyl-L-tert-leucine

benzyl-methyl-amine

Downstream raw materials:

(S)-N,N-benzylmethyl-2-isothiocyanato-3,3-dimethylbutyramide

(2S)-2-({[(1R,2R)-2-aminocyclohexyl]carbamothioyl}amino)-N-benzyl-N,3,3-trimethylbutanamide

1-((S)-1-(N-benzyl-N-methylcarbamoyl)-2,2-dimethylpropyl)-3-(3,5-bis(trifluoromethyl)phenyl)thiourea

(S)-t-leucine N-benzyl-N-methyl-amide