Chiral Bicyclic Guanidine(CBG9)

Base Information

Chemical Name:Chiral Bicyclic Guanidine(CBG9)
CAS No.:127042-91-5
Molecular Formula:C₁₇H₂₉N₃
Molecular Weight:275.437
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Chiral Bicyclic Guanidine(CBG9)

Chemical Property:

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Technology Process of Chiral Bicyclic Guanidine(CBG9)

There total 13 articles about Chiral Bicyclic Guanidine(CBG9) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 127042-97-1
[(R)-1-Cyclohexyl-2-((R)-4-cyclohexyl-2-methylsulfanyl-4,5-dihydro-imidazol-1-yl)-ethyl]-trityl-amine; hydriodide

: 127042-91-5
3R,7R-dicyclohexyl-1,4,6-triazabicyclo<3.3.0.>oct-4-ene

Guidance literature:: In N,N-dimethyl-formamide; at 120 ℃; for 1h; Heating;
DOI:10.1016/S0040-4039(01)93748-7

Reference yield:

: 24461-61-8
(R)-Phenylglycine methyl ester

: 127042-91-5
3R,7R-dicyclohexyl-1,4,6-triazabicyclo<3.3.0.>oct-4-ene

Guidance literature:: Multi-step reaction with 10 steps

1: 84 percent / ammonia / methanol / 1.) 0 deg C for 3 h, 2.) 22 deg C for 16 h

2: 87 percent / H₂ / Admams' Pt / acetic acid / 40 h / 23 °C / 760 Torr

3: 94 percent / triethylamine / CH₂Cl₂ / 2.5 h / 23 °C

4: 97 percent / lithium aluminium hydride / diethyl ether / 40 h / Heating

5: 85 percent / tetrahydrofuran

6: 100 percent / H₂ / Pd-C / methanol / 23 °C / 760 Torr

7: 100 percent / bis(2-methoxyethoxy)aluminium dihydride / benzene / 0.67 h / Heating

8: 69 percent / triethylamine / 1.)-50 deg C to -30 deg C for 2 h, 2.)23 deg C 1 h

9: 100 percent / methanol / 0.75 h / 60 °C

10: 60 percent / dimethylformamide / 1 h / 120 °C / Heating

With lithium aluminium tetrahydride; bis(2-methoxyethoxy)aluminium dihydride; ammonia; hydrogen; triethylamine; platinum(IV) oxide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetic acid; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4039(01)93748-7

Reference yield:

: 127042-98-2
D-(-)-cyclohexylglycine amide

: 127042-91-5
3R,7R-dicyclohexyl-1,4,6-triazabicyclo<3.3.0.>oct-4-ene

Guidance literature:: Multi-step reaction with 8 steps

1: 94 percent / triethylamine / CH₂Cl₂ / 2.5 h / 23 °C

2: 97 percent / lithium aluminium hydride / diethyl ether / 40 h / Heating

3: 85 percent / tetrahydrofuran

4: 100 percent / H₂ / Pd-C / methanol / 23 °C / 760 Torr

5: 100 percent / bis(2-methoxyethoxy)aluminium dihydride / benzene / 0.67 h / Heating

6: 69 percent / triethylamine / 1.)-50 deg C to -30 deg C for 2 h, 2.)23 deg C 1 h

7: 100 percent / methanol / 0.75 h / 60 °C

8: 60 percent / dimethylformamide / 1 h / 120 °C / Heating

With lithium aluminium tetrahydride; bis(2-methoxyethoxy)aluminium dihydride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4039(01)93748-7