[(R)-1-Cyclohexyl-2-((R)-4-cyclohexyl-2-methylsulfanyl-4,5-dihydro-imidazol-1-yl)-ethyl]-trityl-amine; hydriodide

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Chemical Name:[(R)-1-Cyclohexyl-2-((R)-4-cyclohexyl-2-methylsulfanyl-4,5-dihydro-imidazol-1-yl)-ethyl]-trityl-amine; hydriodide
CAS No.:127042-97-1
Molecular Formula:C₃₇H₄₇N₃S*HI
Molecular Weight:693.779
Hs Code.:

Synonyms:[(R)-1-Cyclohexyl-2-((R)-4-cyclohexyl-2-methylsulfanyl-4,5-dihydro-imidazol-1-yl)-ethyl]-trityl-amine; hydriodide

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Chemical Property of [(R)-1-Cyclohexyl-2-((R)-4-cyclohexyl-2-methylsulfanyl-4,5-dihydro-imidazol-1-yl)-ethyl]-trityl-amine; hydriodide

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Technology Process of [(R)-1-Cyclohexyl-2-((R)-4-cyclohexyl-2-methylsulfanyl-4,5-dihydro-imidazol-1-yl)-ethyl]-trityl-amine; hydriodide

There total 11 articles about [(R)-1-Cyclohexyl-2-((R)-4-cyclohexyl-2-methylsulfanyl-4,5-dihydro-imidazol-1-yl)-ethyl]-trityl-amine; hydriodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 127042-96-0
(R)-4-Cyclohexyl-1-[(R)-2-cyclohexyl-2-(trityl-amino)-ethyl]-imidazolidine-2-thione

: 74-88-4
methyl iodide

: 127042-97-1
[(R)-1-Cyclohexyl-2-((R)-4-cyclohexyl-2-methylsulfanyl-4,5-dihydro-imidazol-1-yl)-ethyl]-trityl-amine; hydriodide

Guidance literature:: In methanol; at 60 ℃; for 0.75h;
DOI:10.1016/S0040-4039(01)93748-7

Reference yield:

: 700-63-0,6485-52-5,6485-67-2,58429-87-1
(R)-phenylglycine amide

: 127042-97-1
[(R)-1-Cyclohexyl-2-((R)-4-cyclohexyl-2-methylsulfanyl-4,5-dihydro-imidazol-1-yl)-ethyl]-trityl-amine; hydriodide

Guidance literature:: Multi-step reaction with 8 steps

1: 87 percent / H₂ / Admams' Pt / acetic acid / 40 h / 23 °C / 760 Torr

2: 94 percent / triethylamine / CH₂Cl₂ / 2.5 h / 23 °C

3: 97 percent / lithium aluminium hydride / diethyl ether / 40 h / Heating

4: 85 percent / tetrahydrofuran

5: 100 percent / H₂ / Pd-C / methanol / 23 °C / 760 Torr

6: 100 percent / bis(2-methoxyethoxy)aluminium dihydride / benzene / 0.67 h / Heating

7: 69 percent / triethylamine / 1.)-50 deg C to -30 deg C for 2 h, 2.)23 deg C 1 h

8: 100 percent / methanol / 0.75 h / 60 °C

With lithium aluminium tetrahydride; bis(2-methoxyethoxy)aluminium dihydride; hydrogen; triethylamine; platinum(IV) oxide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetic acid; benzene;
DOI:10.1016/S0040-4039(01)93748-7

Reference yield:

: 127042-98-2
D-(-)-cyclohexylglycine amide

: 127042-97-1
[(R)-1-Cyclohexyl-2-((R)-4-cyclohexyl-2-methylsulfanyl-4,5-dihydro-imidazol-1-yl)-ethyl]-trityl-amine; hydriodide

Guidance literature:: Multi-step reaction with 7 steps

1: 94 percent / triethylamine / CH₂Cl₂ / 2.5 h / 23 °C

2: 97 percent / lithium aluminium hydride / diethyl ether / 40 h / Heating

3: 85 percent / tetrahydrofuran

4: 100 percent / H₂ / Pd-C / methanol / 23 °C / 760 Torr

5: 100 percent / bis(2-methoxyethoxy)aluminium dihydride / benzene / 0.67 h / Heating

6: 69 percent / triethylamine / 1.)-50 deg C to -30 deg C for 2 h, 2.)23 deg C 1 h

7: 100 percent / methanol / 0.75 h / 60 °C

With lithium aluminium tetrahydride; bis(2-methoxyethoxy)aluminium dihydride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; benzene;
DOI:10.1016/S0040-4039(01)93748-7