N-[(1R,2R)-2-aMino-1,2-diphenylethyl]-N'-[3,5-bis(trifluoroMethyl)phenyl]-Thiourea

Base Information

• Chemical Name: N-[(1R,2R)-2-aMino-1,2-diphenylethyl]-N'-[3,5-bis(trifluoroMethyl)phenyl]-Thiourea
• CAS No.: 1088705-53-6
• Molecular Formula: C23H19F6N3S
• Molecular Weight: 483.48
• Mol file: 1088705-53-6.mol

Synonyms:1-((1R,2R)-2-Amino-1,2-diphenylethyl)-3-(3,5-bis(trifluoromethyl)phenyl)thiourea;N-[(1R,2R)-2-aMino-1,2-diphenylethyl]-N'-[3,5-bis(trifluoroMethyl)phenyl]-Thiourea;Thiourea, N-[(1R,2R)-2-amino-1,2-diphenylethyl]-N'-[3,5-bis(trifluoromethyl)phenyl]-

Chemical Property of N-[(1R,2R)-2-aMino-1,2-diphenylethyl]-N'-[3,5-bis(trifluoroMethyl)phenyl]-Thiourea

Chemical Property:

• Melting Point: 91-93 °C
• Boiling Point: 487.6±55.0 °C(Predicted)
• PKA: 11.51±0.70(Predicted)
• PSA: 82.17000
• Density: 1.384±0.06 g/cm3(Predicted)
• LogP: 7.61610

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-((1R,2R)-2-Amino-1,2-diphenylethyl)-3-(3,5-bis(trifluoromethyl)phenyl)thiourea >97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[(1R,2R)-2-aMino-1,2-diphenylethyl]-N'-[3,5-bis(trifluoroMethyl)phenyl]-Thiourea

There total 2 articles about N-[(1R,2R)-2-aMino-1,2-diphenylethyl]-N'-[3,5-bis(trifluoroMethyl)phenyl]-Thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3,5-bistrifluoromethylphenylisothiocyanate (23165-29-9) + (R,R)-1,2-diphenylethylenediamine (35132-20-8) → (1R,2R)-1-(2-amino-1,2-diphenylethyl)-3-(3,5-bis(trifluoromethyl)phenyl)thiourea (1088705-53-6)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 5.5h;

DOI:10.1039/c0ob00154f

Reference yield: 90.0%

→ (1R,2R)-1-(2-amino-1,2-diphenylethyl)-3-(3,5-bis(trifluoromethyl)phenyl)thiourea (1088705-53-6)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 15h;

Reference yield: 85.0%

4-Trifluoromethylbenzaldehyde (455-19-6) + (1R,2R)-1-(2-amino-1,2-diphenylethyl)-3-(3,5-bis(trifluoromethyl)phenyl)thiourea (1088705-53-6) → C31H24F9N3S (1088705-57-0)

Guidance literature:

With sodium tris(acetoxy)borohydride; In dichloromethane; at 0 ℃;

DOI:10.1002/chem.200801170

upstream raw materials:

3,5-bistrifluoromethylphenylisothiocyanate

(R,R)-1,2-diphenylethylenediamine

Downstream raw materials:

C₃₁H₂₄F₉N₃S

C₂₇H₂₇F₆N₃S

C₃₀H₃₁F₆N₃S

(S)-tert-butyl-2-[(1R,2R)-2-{3-[3,5-bis(trifluoromethyl)phenyl]thioureido}-1,2-diphenylethylcarbamoyl]pyrrolidine-1-carboxylate