N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide

Base Information

Chemical Name:N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide
CAS No.:1211565-08-0
Molecular Formula:C22H26F3N3O2
Molecular Weight:421.463
Hs Code.:
Mol file:1211565-08-0.mol

Synonyms:N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N inverted exclamation marka-[4-(trifluoromethyl)phenyl]squaramide;3-((1R,2R)-2-(piperidin-1-yl)cyclohexylamino)-4-(4-(trifluoromethyl)phenylamino)cyclobut-3-ene-1,2-dione;Rawal Squaramide Organocatalyst;3-{[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino}-4-{[4-(trifluoromethyl)phenyl]amino}-3-cyclobutene-1,2-dione;

Suppliers and Price of N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Strem Chemicals
3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione, 98%, (99% ee)
50mg
$ 94.00

Sigma-Aldrich
N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoromethyl)phenyl]squaramide 95%
100mg
$ 88.80

Sigma-Aldrich
N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoromethyl)phenyl]squaramide 95%
500mg
$ 360.00

ChemScene
3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione
100mg
$ 142.00

Total 8 raw suppliers

Chemical Property of N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide

Chemical Property:

Melting Point:250 °C (decomp)
Boiling Point:497.4±55.0 °C(Predicted)
PKA:8.97±0.20(Predicted)
PSA：61.44000
Density:1.31±0.1 g/cm3(Predicted)
LogP:3.79480

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione, 98%, (99% ee) ^*data from reagent suppliers

Safty Information:

Pictogram(s): C
Hazard Codes:C
Statements: 37/38-41
Safety Statements: 26-39

MSDS Files:: SDS file from LookChem

Useful:

Uses It can act as a catalyst for the asymmetric tandem aza-Michael addition-protonation between 1-nitro cyclohexene and 4-methoxyaniline to form the corresponding α-arylamino-β-nitro cyclohexane in a 35:65 trans/cis mixture.

Technology Process of N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide

There total 2 articles about N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 885677-91-8,824938-80-9,824938-98-9
(1R,2R)-N¹-piperidinyl-1,2-diaminocyclohexane

: 455-14-1
4-trifluoromethylphenylamine

: 5222-73-1
3,4-dimethoxy-3-cyclobutene-1,2-dione

: 1211565-08-0
3-((1R,2R)-2-(piperidin-1-yl)cyclohexylamino)-4-(4-(trifluoromethyl)phenylamino)cyclobut-3-ene-1,2-dione

Guidance literature:: 4-trifluoromethylphenylamine; 3,4-dimethoxy-3-cyclobutene-1,2-dione; In methanol; at 20 ℃; for 48h;

(1R,2R)-N¹-piperidinyl-1,2-diaminocyclohexane; In methanol; for 3h;