N'-(2-furylmethylene)-2-hydroxybenzohydrazide

Base Information

• Chemical Name: N'-(2-furylmethylene)-2-hydroxybenzohydrazide
• CAS No.: 22596-74-3
• Molecular Formula: C12H10 N2 O3
• Molecular Weight: 230.223
• European Community (EC) Number: 660-260-1
• NSC Number: 241587
• DSSTox Substance ID: DTXSID30425904
• Mol file: 22596-74-3.mol

Synonyms:22596-74-3;N'-(2-furylmethylene)-2-hydroxybenzohydrazide;N'-(Furan-2-ylmethylene)-2-hydroxybenzohydrazide;N'-[(E)-2-Furylmethylidene]-2-hydroxybenzohydrazide;N'-[(E)-(Furan-2-yl)methylidene]-2-hydroxybenzohydrazide;NSC241587;N-[(E)-furan-2-ylmethylideneamino]-2-hydroxybenzamide;SCHEMBL1562168;DTXSID30425904;UFRXXSYMUOQOKX-MDWZMJQESA-N;STK031116;Salicylic acid, furfurylidenehydrazide;AKOS000484964;NSC-241587;2-Hydroxybenzamide-N-(2-furyl)methylidenamino;N'-[(E)-2-Furylmethylidene]-2-hydroxybenzohydrazide #;N'-[(E)-furan-2-ylmethylidene]-2-hydroxybenzohydrazide

Chemical Property of N'-(2-furylmethylene)-2-hydroxybenzohydrazide

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 230.06914219
• Heavy Atom Count: 17
• Complexity: 294

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)NN=CC2=CC=CO2)O
• Isomeric SMILES: C1=CC=C(C(=C1)C(=O)N/N=C/C2=CC=CO2)O

Technology Process of N'-(2-furylmethylene)-2-hydroxybenzohydrazide

There total 3 articles about N'-(2-furylmethylene)-2-hydroxybenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

furfural (98-01-1) + 2-Hydroxybenzoylhydrazine (936-02-7) → 2‐hydroxy‐N′‐(furan‐2‐methylene)‐2‐benzoylhydrazine (22596-74-3)

Guidance literature:

In ethanol; at 85 ℃; for 4h;

DOI:10.1002/bio.3583

Reference yield:

furfural (98-01-1) + 2-Hydroxybenzoylhydrazine (936-02-7) → 2-hydroxy-benzoic acid furfurylidenehydrazide (22596-74-3)

Guidance literature:

With ethanol;

DOI:10.1002/ardp.19552880109

Reference yield:

methyl salicylate (119-36-8,8024-54-2) → 2‐hydroxy‐N′‐(furan‐2‐methylene)‐2‐benzoylhydrazine (22596-74-3)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 10 h / 80 °C / Alkaline conditions

2: ethanol / 4 h / 85 °C

In ethanol;

DOI:10.1002/bio.3583

upstream raw materials:

furfural

2-Hydroxybenzoylhydrazine

methyl salicylate

Downstream raw materials:

{UO₂(C₄H₃OCHNNHCOC₆H₄OH)(NO₃)2}