2-Pyrimidinamine, N-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

Base Information

• Chemical Name: 2-Pyrimidinamine, N-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
• CAS No.: 904326-88-1
• Molecular Formula: C11H18BN3O2
• Molecular Weight: 235.094
• Hs Code.: 2934999090
• Mol file: 904326-88-1.mol

Synonyms:2-Pyrimidinamine, N-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;2-Methylaminopyrimidine-5-boronic acid, pinacol ester;N-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine

Chemical Property of 2-Pyrimidinamine, N-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

Chemical Property:

• Melting Point: 122-125℃
• PSA: 59.50000
• LogP: 0.23940
• Storage Temp.: 2-8°C

Purity/Quality:

≥99% ^*data from raw suppliers

N-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(Methylamino)pyrimidine-5-boronic acid pinacol ester is used as pharmaceutical intermediate.

Technology Process of 2-Pyrimidinamine, N-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

There total 3 articles about 2-Pyrimidinamine, N-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-bromo-N-methylpyrimidin-2-amine (31402-54-7) + bis(pinacol)diborane (73183-34-3) → methyl[5-(4,4,5,5-tetramethyl(1,3,2-dioxaborolan-2-yl))pyrimidin-2-yl]amine (904326-88-1)

Guidance literature:

With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N-dimethyl-formamide; at 80 ℃; for 2h; Inert atmosphere;

Reference yield: 93.0%

5-Bromo-2-chloropyrimidine (32779-36-5) + bis(pinacol)diborane (73183-34-3) → methyl[5-(4,4,5,5-tetramethyl(1,3,2-dioxaborolan-2-yl))pyrimidin-2-yl]amine (904326-88-1)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 80 ℃; for 3h;

Reference yield: 50.0%

→ methyl[5-(4,4,5,5-tetramethyl(1,3,2-dioxaborolan-2-yl))pyrimidin-2-yl]amine (904326-88-1)

Guidance literature:

upstream raw materials:

5-bromo-N-methylpyrimidin-2-amine

bis(pinacol)diborane

5-Bromo-2-chloropyrimidine

Downstream raw materials:

4-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-6-methyl-9-[2-(methylamino)pyrimidin-5-yl]-7-(propan-2-yloxy)-3,4-dihydro-1,4-benzoxazepin-5(2H)-one