1-(3-Tetrahydrofuryl)-1H-...

Base Information

• Chemical Name: 1-(3-Tetrahydrofuryl)-1H-...
• CAS No.: 1029715-63-6
• Molecular Formula: C13H21BN2O3
• Molecular Weight: 282.14372
• Hs Code.: 2934999090
• Mol file: 1029715-63-6.mol

Synonyms:1-(3-Tetrahydrofuryl)-1H-...;1-(tetrahydrofuran-3-yl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1-Tetrahydrofuran-3-yl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyrazole;1-(3-Tetrahydrofuryl)-1H-pyrazole-4-boronic acid pinacol ester

Chemical Property of 1-(3-Tetrahydrofuryl)-1H-...

Chemical Property:

• Boiling Point: 399.3±32.0 °C(Predicted)
• PKA: 2.63±0.19(Predicted)
• PSA: 45.51000
• Density: 1.18±0.1 g/cm3(Predicted)
• LogP: 1.14370
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(Oxolan-3-yl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3-Tetrahydrofuryl)-1H-...

There total 3 articles about 1-(3-Tetrahydrofuryl)-1H-... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

→ 1-(tetrahydrofuran-3-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (1029715-63-6)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In dimethyl sulfoxide; at 80 ℃; for 2h; Inert atmosphere;

Reference yield: 65.6%

rac-4-bromo-1-(tetrahydrofuran-3-yl)-1H-pyrazole (1040377-07-8) + bis(pinacol)diborane (73183-34-3) → 1-(tetrahydrofuran-3-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (1029715-63-6)

Guidance literature:

rac-4-bromo-1-(tetrahydrofuran-3-yl)-1H-pyrazole; bis(pinacol)diborane; With potassium acetate; In N,N-dimethyl-formamide; for 0.166667h;

(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 80 ℃;

Reference yield:

pyrazole-4-boronic acid pinacol ester (269410-08-4) + methanesulfonic acid tetrahydro-furan-3-yl ester (156380-34-6) → 1-(tetrahydrofuran-3-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (1029715-63-6)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 60 ℃; for 48h;

upstream raw materials:

pyrazole-4-boronic acid pinacol ester

methanesulfonic acid tetrahydro-furan-3-yl ester

rac-4-bromo-1-(tetrahydrofuran-3-yl)-1H-pyrazole

bis(pinacol)diborane

Refernces

• 1、 -. "ALKENYL COMPOUNDS AND METHODS OF USE". Paragraph 0262. . Retrieved 2014/12/12.
• 2、 -. "IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS". Page/Page column 90. . Retrieved 2008/12/05.