6-Chloro-4-phenethyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxylic acid

Base Information

Chemical Name:6-Chloro-4-phenethyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxylic acid
CAS No.:134372-54-6
Molecular Formula:C17H16ClNO3
Molecular Weight:317.76684
Hs Code.:
Mol file:134372-54-6.mol

Synonyms:2H-1,4-Benzoxazine-8-carboxylic acid, 6-chloro-3,4-dihydro-4-(2-phenylethyl)-;

Suppliers and Price of 6-Chloro-4-phenethyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-Chloro-4-phenethyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxylic acid

Chemical Property:

Melting Point:128 - 129 °C (diisopropyl ether)
PSA：49.77000
LogP:3.54470

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 6-Chloro-4-phenethyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxylic acid

There total 7 articles about 6-Chloro-4-phenethyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1026977-93-4
6-Chloro-4-phenethyl-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxylic acid methyl ester

: 134372-54-6
6-Chloro-4-(2-phenylethyl)-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; at 50 - 55 ℃; for 3h; Yield given;
DOI:10.1248/cpb.44.756

Reference yield:

: 149140-78-3
ethyl 3-aminio-5-chloro-2-hydroxybenzoate

: 134372-54-6
6-Chloro-4-(2-phenylethyl)-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / aq. NaHCO₃ / CHCl₃ / 2 h / 0 - 10 °C

2: 88 percent / K₂CO₃ / dimethylformamide / 3 h / 70 - 75 °C

3: 93 percent / aq. NaOH / methanol / 3 h / Heating

4: 95 percent / conc. H₂SO₄ / 10 h / Heating

5: HCl, NaBH₃CN / methanol; ethanol / 8 h / Ambient temperature

6: aq. NaOH / methanol / 3 h / 50 - 55 °C

With hydrogenchloride; sodium hydroxide; sulfuric acid; sodium cyanoborohydride; sodium hydrogencarbonate; potassium carbonate; In methanol; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1248/cpb.44.756

Reference yield:

: 139329-90-1
N-(3-ethoxycarbonyl-5-chloro-2-hydroxyphenyl)acetamide

: 134372-54-6
6-Chloro-4-(2-phenylethyl)-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / K₂CO₃ / dimethylformamide / 3 h / 70 - 75 °C

2: 93 percent / aq. NaOH / methanol / 3 h / Heating

3: 95 percent / conc. H₂SO₄ / 10 h / Heating

4: HCl, NaBH₃CN / methanol; ethanol / 8 h / Ambient temperature

5: aq. NaOH / methanol / 3 h / 50 - 55 °C

With hydrogenchloride; sodium hydroxide; sulfuric acid; sodium cyanoborohydride; potassium carbonate; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.44.756