Ethyl 3-acetamido-5-chloro-2-hydroxybenzoate

Base Information

• Chemical Name: Ethyl 3-acetamido-5-chloro-2-hydroxybenzoate
• CAS No.: 139329-90-1
• Molecular Formula: C11H12ClNO4
• Molecular Weight: 257.67000
• Mol file: 139329-90-1.mol

Synonyms:

Chemical Property of Ethyl 3-acetamido-5-chloro-2-hydroxybenzoate

Chemical Property:

• PSA: 75.63000
• LogP: 2.25370
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Ethyl3-acetamido-5-chloro-2-hydroxybenzoate 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 3-acetamido-5-chloro-2-hydroxybenzoate

There total 1 articles about Ethyl 3-acetamido-5-chloro-2-hydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

acetyl chloride (75-36-5) + ethyl 3-aminio-5-chloro-2-hydroxybenzoate (149140-78-3) → N-(3-ethoxycarbonyl-5-chloro-2-hydroxyphenyl)acetamide (139329-90-1)

Guidance literature:

With sodium hydrogencarbonate; In chloroform; at 0 - 10 ℃; for 2h;

DOI:10.1248/cpb.44.756

Reference yield: 86.0%

N-(3-ethoxycarbonyl-5-chloro-2-hydroxyphenyl)acetamide (139329-90-1) + 1-chloro-3-hydroxypropane (627-30-5) → 3-Acetylamino-5-chloro-2-(3-hydroxy-propoxy)-benzoic acid ethyl ester (185629-61-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 70 - 75 ℃; for 4h;

DOI:10.1248/cpb.44.2051

Reference yield: 86.0%

N-(3-ethoxycarbonyl-5-chloro-2-hydroxyphenyl)acetamide (139329-90-1) + methyl iodide (74-88-4) → N-(3-ethoxycarbonyl-5-chloro-2-methoxyphenyl)acetamide (177212-80-5)

Guidance literature:

With potassium carbonate; In acetone; for 3h; Ambient temperature;

DOI:10.1248/cpb.44.756

upstream raw materials:

acetyl chloride

ethyl 3-aminio-5-chloro-2-hydroxybenzoate

Downstream raw materials:

3-Acetylamino-5-chloro-2-(3-hydroxy-propoxy)-benzoic acid ethyl ester

N-(3-ethoxycarbonyl-5-chloro-2-methoxyphenyl)acetamide

6-chloro-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylic acid

5-chloro-2-methoxy-3-(N-methylacetylamino)benzoic acid