(2S)-N-((1R)-2-amino-1-(4-((2-methylpentyl)oxy)phenyl)ethyl)-2-phenylpropanamide

Base Information

Chemical Name:(2S)-N-((1R)-2-amino-1-(4-((2-methylpentyl)oxy)phenyl)ethyl)-2-phenylpropanamide
CAS No.:1287285-96-4
Molecular Formula:C23H32N2O2
Molecular Weight:368.519
Hs Code.:
Mol file:1287285-96-4.mol

Synonyms:[(2S)-N-((1R)-2-amino-1-(4-(2-methylpentyloxy)-phenyl)ethyl)-2-phenylpropanamide];(2S)-N-((1R)-2-amino-1-(4-(2-methylpentyloxy)phenyl)ethyl)-2-phenyl-propanamide;

Suppliers and Price of (2S)-N-((1R)-2-amino-1-(4-((2-methylpentyl)oxy)phenyl)ethyl)-2-phenylpropanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of (2S)-N-((1R)-2-amino-1-(4-((2-methylpentyl)oxy)phenyl)ethyl)-2-phenylpropanamide

Chemical Property:

PSA：64.35000
LogP:5.51250

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S)-N-((1R)-2-amino-1-(4-((2-methylpentyl)oxy)phenyl)ethyl)-2-phenylpropanamide

There total 8 articles about (2S)-N-((1R)-2-amino-1-(4-((2-methylpentyl)oxy)phenyl)ethyl)-2-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7782-24-3
(S)-2-Phenylpropionic acid

: 1287285-96-4
(2S)-N-{(1R)-2-amino-1-[4-(2-methylpentyloxy)phenyl]ethyl}-2-phenylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 2068.65 Torr

With hydrogen; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In ethanol; dichloromethane;

Reference yield:

: 143323-49-3,141518-55-0
(R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate

: 1287285-96-4
(2S)-N-{(1R)-2-amino-1-[4-(2-methylpentyloxy)phenyl]ethyl}-2-phenylpropanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: triphenylphosphine / tetrahydrofuran / 0.17 h

1.2: 18 h / 20 °C

2.1: lithium chloride; sodium tetrahydroborate / ethanol; tetrahydrofuran / 0 - 20 °C

2.2: 0 °C

3.1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

4.1: sodium azide / N,N-dimethyl-formamide / 1 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

7.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 2068.65 Torr

With sodium tetrahydroborate; sodium azide; carbon tetrabromide; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; lithium chloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1286280-72-5
tert-butyl (1R)-2-hydroxy-1-[4-(2-methylpentyloxy)phenyl]ethylcarbamate

: 1287285-96-4
(2S)-N-{(1R)-2-amino-1-[4-(2-methylpentyloxy)phenyl]ethyl}-2-phenylpropanamide

Guidance literature:: Multi-step reaction with 5 steps

1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

2: sodium azide / N,N-dimethyl-formamide / 1 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

5: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 2068.65 Torr

With sodium azide; carbon tetrabromide; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;