(2S)-N-((1R)-2-(dimethylamino)-1-(4-(2-methylpentyloxy)phenyl)ethyl)-2-phenylpropanamide trifluoroacetate

Base Information

Chemical Name:(2S)-N-((1R)-2-(dimethylamino)-1-(4-(2-methylpentyloxy)phenyl)ethyl)-2-phenylpropanamide trifluoroacetate
CAS No.:1287286-09-2
Molecular Formula:C₂HF₃O₂*C₂₅H₃₆N₂O₂
Molecular Weight:510.597
Hs Code.:

Synonyms:(2S)-N-((1R)-2-(dimethylamino)-1-(4-(2-methylpentyloxy)phenyl)ethyl)-2-phenylpropanamide trifluoroacetate

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Chemical Property of (2S)-N-((1R)-2-(dimethylamino)-1-(4-(2-methylpentyloxy)phenyl)ethyl)-2-phenylpropanamide trifluoroacetate

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Technology Process of (2S)-N-((1R)-2-(dimethylamino)-1-(4-(2-methylpentyloxy)phenyl)ethyl)-2-phenylpropanamide trifluoroacetate

There total 10 articles about (2S)-N-((1R)-2-(dimethylamino)-1-(4-(2-methylpentyloxy)phenyl)ethyl)-2-phenylpropanamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1287285-96-4
(2S)-N-{(1R)-2-amino-1-[4-(2-methylpentyloxy)phenyl]ethyl}-2-phenylpropanamide

: 76-05-1
trifluoroacetic acid

: 1287286-09-2
(2S)-N-((1R)-2-(dimethylamino)-1-(4-(2-methylpentyloxy)phenyl)ethyl)-2-phenylpropanamide trifluoroacetate

Guidance literature:: formaldehyd; (2S)-N-{(1R)-2-amino-1-[4-(2-methylpentyloxy)phenyl]ethyl}-2-phenylpropanamide; In water; acetonitrile; for 0.25h;

With sodium tris(acetoxy)borohydride; In water; acetonitrile; at 20 ℃; for 1h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 143323-49-3,141518-55-0
(R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate

: 1287286-09-2
(2S)-N-((1R)-2-(dimethylamino)-1-(4-(2-methylpentyloxy)phenyl)ethyl)-2-phenylpropanamide trifluoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: triphenylphosphine / tetrahydrofuran / 0.17 h

1.2: 18 h / 20 °C

2.1: lithium chloride; sodium tetrahydroborate / ethanol; tetrahydrofuran / 0 - 20 °C

2.2: 0 °C

3.1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

4.1: sodium azide / N,N-dimethyl-formamide / 1 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

7.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 2068.65 Torr

8.1: acetonitrile; water / 0.25 h

8.2: 1 h / 20 °C

With sodium tetrahydroborate; sodium azide; carbon tetrabromide; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; lithium chloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 7782-24-3
(S)-2-Phenylpropionic acid

: 1287286-09-2
(2S)-N-((1R)-2-(dimethylamino)-1-(4-(2-methylpentyloxy)phenyl)ethyl)-2-phenylpropanamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 2068.65 Torr

3.1: acetonitrile; water / 0.25 h

3.2: 1 h / 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In ethanol; dichloromethane; water; acetonitrile;