(1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylic acid

Base Information

Chemical Name:(1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylic acid
CAS No.:220352-36-3
Molecular Formula:C10H8F2O2
Molecular Weight:198.169
Hs Code.:2916200090
DSSTox Substance ID:DTXSID60431457
Nikkaji Number:J2.688.118H
Mol file:220352-36-3.mol

Synonyms:220352-36-3;(1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylic acid;(1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylic Acid;trans-2-(3,4-Difluoro-phenyl)-cyclopropanecarboxylic acid;1006614-50-1;trans-2-(3,4-Difluorophenyl)cyclopropanecarboxylic acid;(1R,2R)-2-(3,4-Difluorophenyl)-cyclopropanecarboxylic Acid;MFCD22201080;SCHEMBL248384;AMY3283;DTXSID60431457;CS-M1813;Cyclopropanecarboxylic acid, 2-(3,4-difluorophenyl)-, (1R,2R)-;AC9689;AKOS016844814;CS-14545;EN300-1655713;trans-2-(3,4-Difluorophenyl)cyclopropanecarboxylicacid;Z2307311644;(1R,2R)-2-(3,4-Difluorophenyl) Cyclopropane Carboxylic Acid;(1R,2R)-2-(3,4-difluorophenyl)-1-cyclopropanecarboxylic acid;(1R,2R)-2-(3,4-Difluorophenyl)Cyclopropane Carboxylic Acid;rac-(1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylic acid;(1r,2s)-2-(3,4-difluorophenyl)cyclopropanaminium (2r)hydroxy(phenyl)ethanoate

Suppliers and Price of (1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(1R,2R)-2-(3,4-Difluorophenyl)-cyclopropanecarboxylicAcid
500mg
$ 460.00

TRC
(1R,2R)-2-(3,4-Difluorophenyl)-cyclopropanecarboxylicAcid
100mg
$ 185.00

Crysdot
(1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylicacid 95+%
1g
$ 772.00

ChemScene
(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylicacid
100mg
$ 155.00

Chemenu
(1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylicacid 95%
1g
$ 729.00

Apolloscientific
(1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylicacid 97%
250mg
$ 1147.00

Apolloscientific
(1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylicacid 97%
100mg
$ 699.00

American Custom Chemicals Corporation
(1R,2R)-2-(3,4-DIFLUOROPHENYL)CYCLOPROPANECARBOXYLIC ACID 95.00%
5MG
$ 502.22

Alichem
(1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylicacid
1g
$ 621.72

AK Scientific
(1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylicacid
10g
$ 2278.00

Total 65 raw suppliers

Chemical Property of (1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylic acid

Chemical Property:

Boiling Point:308.1±42.0 °C(Predicted)
PKA:4.53±0.10(Predicted)
PSA：37.30000
Density:1.435±0.06 g/cm3(Predicted)
LogP:2.15290
Storage Temp.:Sealed in dry,Room Temperature
Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Sparingly)
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:198.04923582
Heavy Atom Count:14
Complexity:244

Purity/Quality:

99% ^*data from raw suppliers

(1R,2R)-2-(3,4-Difluorophenyl)-cyclopropanecarboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(C1C(=O)O)C2=CC(=C(C=C2)F)F
Isomeric SMILES:C1[C@H]([C@@H]1C(=O)O)C2=CC(=C(C=C2)F)F
Uses (1R,2R)-2-(3,4-Difluorophenyl)-cyclopropanecarboxylic Acid is an intermediate used to prepare AZD6140 as an orally active reversible P2Y12 receptor antagonist for prevention of thrombosis. It is also used to synthesize triazolopyrimidine derivatives as P2T receptor antagonists.

Technology Process of (1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylic acid

There total 25 articles about (1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: [3aS-[1(1R,2R),3a,6,7a]]-1-[[2-(3,4-difluorophenyl)cyclopropyl]carbonyl]-hexahydro-8,8-dimethyl-3H-3a,6-methano-2,1-benzisothiazole-2,2-dioxide

: 220352-36-3,1006614-50-1
trans-(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; at 50 ℃;
DOI:10.1016/j.bmcl.2007.07.057

Reference yield: 98.1%

: (4R,5R)-2-[(1R,2R)-2-(3,4-difluorophenyl)cyclopropyl]-1,3-dioxolane-4,5-dicarboxylic acid diisopropyl ester

: 220352-36-3,1006614-50-1
trans-(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid

Guidance literature:: With Jones reagent; In acetone; at 0 - 5 ℃;

Reference yield: 98.0%

: 1006376-61-9
(1R,2R)-2-(3,4-difluorophenyl)-1-cyclopropanecarboxylic acid ethyl ester

: 220352-36-3,1006614-50-1
trans-(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid

Guidance literature:: (1R,2R)-2-(3,4-difluorophenyl)-1-cyclopropanecarboxylic acid ethyl ester; With methanol; sodium hydroxide; water; In toluene; at 65 ℃; for 2h;

With hydrogenchloride; In water; toluene;