(R)-1-((R)-1-Phenylethyl)azetidine-2-carboxylic acid

Base Information

• Chemical Name: (R)-1-((R)-1-Phenylethyl)azetidine-2-carboxylic acid
• CAS No.: 210883-78-6
• Molecular Formula: C12 H15 NO2
• Molecular Weight: 205.253
• Mol file: 210883-78-6.mol

Synonyms:(R)-1-((R)-1-phenylethyl)azetidine-2-carboxylic acid;(2R)-1-[(1R)-1-PHENYLETHYL]-2-AZETIDINECARBOXYLIC ACID;2-Azetidinecarboxylic acid, 1-[(1R)-1-phenylethyl]-, (2R)-

Chemical Property of (R)-1-((R)-1-Phenylethyl)azetidine-2-carboxylic acid

Chemical Property:

• PSA: 40.54000
• LogP: 1.84440

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-((R)-1-Phenylethyl)azetidine-2-carboxylic acid

There total 13 articles about (R)-1-((R)-1-Phenylethyl)azetidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl (2S,1'S)-1-(1'-methyl)benzylazetidine-2-carboxylate (204274-29-3,186096-46-8) → (2S,1'S)-1-(1'-methyl)benzylazetidine-2-carboxylic acid (204274-33-9,210883-78-6)

Guidance literature:

With Candida antarctica lipase B; water; at 40 ℃; for 2h;

DOI:10.1271/bbb.69.1892

Reference yield:

dimethyl (1'S)-1-(1'-methyl)benzylazetidine-2,2-dicarboxylate (921600-20-6) → (2S,1'S)-1-(1'-methyl)benzylazetidine-2-carboxylic acid (204274-33-9,210883-78-6) + (2R,1'S)-1-(1'-methyl)benzylazetidine-2-carboxylic acid (210883-78-6)

Guidance literature:

dimethyl (1'S)-1-(1'-methyl)benzylazetidine-2,2-dicarboxylate; With 2,6-di-tert-butyl-4-methyl-phenol; 3 A molecular sieve; lithium chloride; In dimethyl sulfoxide; at 20 - 140 ℃; for 3h;

With Candida antarctica lipase B; water; at 17 ℃; for 10h; Further stages.;

DOI:10.1271/bbb.69.1892

Reference yield:

dimethyl (1'S)-1-(1'-methyl)benzylazetidine-2,2-dicarboxylate (921600-20-6) → (2S,1'S)-1-(1'-methyl)benzylazetidine-2-carboxylic acid (204274-33-9,210883-78-6) + (2R,1'S)-1-(1'-methyl)benzylazetidine-2-carboxylic acid (210883-78-6)

Guidance literature:

dimethyl (1'S)-1-(1'-methyl)benzylazetidine-2,2-dicarboxylate; With 2,6-di-tert-butyl-4-methyl-phenol; 3 A molecular sieve; lithium chloride; In dimethyl sulfoxide; at 20 - 140 ℃; for 3h;

With Candida antarctica lipase B; water; at 17 ℃; for 10h; Further stages.;

DOI:10.1271/bbb.69.1892

upstream raw materials:

methyl (2S,1'S)-1-(1'-methyl)benzylazetidine-2-carboxylate

dimethyl (1'S)-1-(1'-methyl)benzylazetidine-2,2-dicarboxylate

dimethyl (1'S)-(1'-methyl)benzylaminomalonate

methyl (2R,1'S)-1-(1'-methyl)benzylazetidine-2-carboxylate