(6-Chloropyrazin-2-yl)methanol

Base Information

• Chemical Name: (6-Chloropyrazin-2-yl)methanol
• CAS No.: 1240602-95-2
• Molecular Formula: C5H5ClN2O
• Molecular Weight: 144.559
• Hs Code.: 2933990090
• Mol file: 1240602-95-2.mol

Synonyms:(6-Chloropyrazin-2-yl)Methanol;6-Chloro-2-pyrazinemethanol

Chemical Property of (6-Chloropyrazin-2-yl)methanol

Chemical Property:

• Boiling Point: 255.7±35.0℃ (760 Torr)
• PKA: 12.39±0.10(Predicted)
• Flash Point: 108.5±25.9℃
• PSA: 46.01000
• Density: 1.422±0.06 g/cm3 (20 oC 760 Torr)
• LogP: 0.62230
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

(6-Chloropyrazin-2-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (6-Chloropyrazin-2-yl)methanol

There total 4 articles about (6-Chloropyrazin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

6-chloro-pyrazine-2-carboxylic acid methyl ester (23611-75-8) → (6-chloropyrazin-2-yl)methanol (1240602-95-2)

Guidance literature:

With sodium tetrahydroborate; water; at 0 - 25 ℃; for 1h;

Reference yield:

methyl pyrazine-2-carboxylate (6164-79-0) → (6-chloropyrazin-2-yl)methanol (1240602-95-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / 1,2-dichloro-ethane / 60 °C

2: thionyl chloride / 85 °C

3: sodium tetrahydroborate / water / 0 - 20 °C

With sodium tetrahydroborate; thionyl chloride; 3-chloro-benzenecarboperoxoic acid; In water; 1,2-dichloro-ethane;

Reference yield:

2-(methoxycarbonyl)pyrazine 1-oxide (85661-24-1) → (6-chloropyrazin-2-yl)methanol (1240602-95-2)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 85 °C

2: sodium tetrahydroborate / water / 0 - 20 °C

With sodium tetrahydroborate; thionyl chloride; In water;

upstream raw materials:

methyl pyrazine-2-carboxylate

2-(methoxycarbonyl)pyrazine 1-oxide

6-chloro-pyrazine-2-carboxylic acid methyl ester

Downstream raw materials:

6-chloropyrazine-2-carbaldehyde

1-(6-chloropyrazin-2-yl)ethanone

Refernces

• 1、 -. "BENZOXAZINONE DERIVATIVES AND ANALOGUES THEREOF AS MODULATORS OF TNF ACTIVITY". Page/Page column 43; 44. . Retrieved 2016/12/26.
• 2、 -. "THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE". . . Retrieved 2015/02/02.