2-Pyridineacetic acid, 5-nitro-, methyl ester

Base Information

• Chemical Name: 2-Pyridineacetic acid, 5-nitro-, methyl ester
• CAS No.: 292600-22-7
• Molecular Formula: C8H8N2O4
• Molecular Weight: 196.16012
• Hs Code.: 2933399090
• Mol file: 292600-22-7.mol

Synonyms:Methyl 5-Nitropyridine-2-acetate;methyl 2-(5-nitro-2-pyridyl)acetate;Methyl 2-(5-nitropyridin-2-yl)acetate;2-Pyridineacetic acid, 5-nitro-, methyl ester

Chemical Property of 2-Pyridineacetic acid, 5-nitro-, methyl ester

Chemical Property:

• PSA: 85.01000
• LogP: 1.22850
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-(5-nitropyridin-2-yl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Pyridineacetic acid, 5-nitro-, methyl ester

There total 5 articles about 2-Pyridineacetic acid, 5-nitro-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

(2-(5-nitropyridin-2-yl)malonate 1-(tert-butyl)-3-methyl ester) (292600-21-6) → methyl 2-(5-nitropyridin-2-yl)acetate (292600-22-7)

Guidance literature:

trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/S0040-4039(01)01322-3

Reference yield: 69.0%

→ methyl 2-(5-nitropyridin-2-yl)acetate (292600-22-7)

Guidance literature:

Reference yield: 42.8%

2-chloro-5-nitropyridine (4548-45-2) + methyl t-butyl malonate (42726-73-8) → methyl 2-(5-nitropyridin-2-yl)acetate (292600-22-7)

Guidance literature:

methyl t-butyl malonate; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.25h;

2-chloro-5-nitropyridine; In tetrahydrofuran; at 20 ℃; for 4h;

upstream raw materials:

(2-(5-nitropyridin-2-yl)malonate 1-(tert-butyl)-3-methyl ester)

2-chloro-5-nitropyridine

dimethyl 2-(5-nitropyridin-2-yl)malonate

methyl t-butyl malonate

Downstream raw materials:

methyl 2-(5-aminopyridin-2-yl)acetate

2-(5-nitropyridin-2-yl)ethanol

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