5-AMino-2-pyridineacetic acid Methyl ester

Base Information

• Chemical Name: 5-AMino-2-pyridineacetic acid Methyl ester
• CAS No.: 174891-11-3
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.18
• Mol file: 174891-11-3.mol

Synonyms:5-AMino-2-pyridineacetic acid Methyl ester

Chemical Property of 5-AMino-2-pyridineacetic acid Methyl ester

Chemical Property:

Purity/Quality:

98%Min ^*data from raw suppliers

5-amino-2-Pyridineaceticacidmethylester 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-AMino-2-pyridineacetic acid Methyl ester

There total 3 articles about 5-AMino-2-pyridineacetic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methyl 2-(5-nitropyridin-2-yl)acetate (292600-22-7) → methyl 2-(5-aminopyridin-2-yl)acetate (174891-11-3)

Guidance literature:

With 5%-palladium/activated carbon; ammonium formate; In ethanol; at 80 ℃; for 1.5h; Inert atmosphere;

DOI:10.1002/anie.201506868

Reference yield:

dimethyl 2-(5-nitropyridin-2-yl)malonate (68719-87-9) → methyl 2-(5-aminopyridin-2-yl)acetate (174891-11-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium chloride / water; dimethyl sulfoxide / 6 h / 130 °C

2: palladium on activated charcoal; hydrogen / methanol / 3 h / 20 °C

With palladium on activated charcoal; hydrogen; sodium chloride; In methanol; water; dimethyl sulfoxide;

Reference yield:

2-chloro-5-nitropyridine (4548-45-2) → methyl 2-(5-aminopyridin-2-yl)acetate (174891-11-3)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 100 °C

2: sodium chloride / water; dimethyl sulfoxide / 6 h / 130 °C

3: palladium on activated charcoal; hydrogen / methanol / 3 h / 20 °C

With palladium on activated charcoal; hydrogen; caesium carbonate; sodium chloride; In methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

upstream raw materials:

methyl 2-(5-nitropyridin-2-yl)acetate

dimethyl 2-(5-nitropyridin-2-yl)malonate

2-chloro-5-nitropyridine

Refernces

• 1、 -. "COMPOUNDS AND THEIR METHODS OF USE". Paragraph 0706; 0712-0714. . Retrieved 2014/05/25.
• 2、 -. "COMPOUNDS AND THEIR METHODS OF USE". Page/Page column 177. . Retrieved 2014/06/11.