4-((R)-2-((R)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-trifluoroMethyl)benzonitrile(LGD-4033)

Base Information

• Chemical Name: 4-((R)-2-((R)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-trifluoroMethyl)benzonitrile(LGD-4033)
• CAS No.: 1165910-22-4
• Molecular Formula: C14H12F6N2O
• Molecular Weight: 338.252
• Mol file: 1165910-22-4.mol

Synonyms:Lgd-4033

Chemical Property of 4-((R)-2-((R)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-trifluoroMethyl)benzonitrile(LGD-4033)

Chemical Property:

• Boiling Point: 439.9±45.0 °C(Predicted)
• PKA: 12.06±0.20(Predicted)
• PSA: 47.26000
• Density: 1.45±0.1 g/cm3 (20 oC 760 Torr), Calc.*
• LogP: 3.53408
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Acetone (Slightly), Chloroform (Slightly, Heated), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

LGD-4033 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: LGD-4033 is a Selective Androgen Receptor Modulator (SARM). SARMs are a class of non-steroidal anabolic agents that bind androgen receptors with high affinity. LGD-4033 has been shown to provide benefits similar to traditional anabolic agents, (e.g., increased muscle mass, fat loss, and improved bone density) but with far fewer side effects (e.g., oily skin, acne, over-conversion to estrogen, etc.). Both men and women may also appreciate improved libido. All of these benefits are achieved without increasing androgen levels. Its anabolic effects are roughly the same or greater than testosterone, even at low doses. Some prescribers will recommend a trial of SARMs for low testosterone levels prior to utilizing testosterone replacement therapy.
• Uses: LGD-4033 is a nonsteroidal oral, selective androgen receptor modulator, in healthy young men.

Technology Process of 4-((R)-2-((R)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-trifluoroMethyl)benzonitrile(LGD-4033)

There total 1 articles about 4-((R)-2-((R)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-trifluoroMethyl)benzonitrile(LGD-4033) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[(2R)-2-formylpyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile (1165910-28-0) + (trifluoromethyl)trimethylsilane (81290-20-2) → 4-(2(R)-(1(S)-hydroxyl-2,2,2-trifluoroethyl)pyrrolidinyl)-2-trifluoromethylbenzonitrile (1165910-23-5,1619264-51-5) + LGD-4033 (1165910-22-4,1619264-51-5)

Guidance literature:

upstream raw materials:

4-[(2R)-2-formylpyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile

(trifluoromethyl)trimethylsilane