1-[(2R,6S)-6-(Hydroxymethyl)-2-morpholinyl]-5-methyl-2,4(1H,3H)-pyrimidinedione

Base Information

Chemical Name:1-[(2R,6S)-6-(Hydroxymethyl)-2-morpholinyl]-5-methyl-2,4(1H,3H)-pyrimidinedione
CAS No.:179073-10-0
Molecular Formula:C10H15N3O4
Molecular Weight:241.24
Hs Code.:
UNII:YML1Y6H5HD
Mol file:179073-10-0.mol

Synonyms:179073-10-0;Morpholino thymidine;1-[(2R,6S)-6-(Hydroxymethyl)-2-morpholinyl]-5-methyl-2,4(1H,3H)-pyrimidinedione;1-((2R,6S)-6-(hydroxymethyl)morpholin-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;YML1Y6H5HD;1-[(2R,6S)-6-(hydroxymethyl)morpholin-2-yl]-5-methylpyrimidine-2,4-dione;1-((2R,6S)-6-(Hydroxymethyl)-2-morpholinyl)-5-methyl-2,4(1H,3H)-pyrimidinedione;1-(6-Hydroxymethyl-morpholin-2-yl)-5-methyl-1H-pyrimidine-2,4-dione;2,4(1H,3H)-Pyrimidinedione, 1-((2R,6S)-6-(hydroxymethyl)-2-morpholinyl)-5-methyl-;UNII-YML1Y6H5HD;SCHEMBL24420143;DB-180597;CS-0100784;A897935

Suppliers and Price of 1-[(2R,6S)-6-(Hydroxymethyl)-2-morpholinyl]-5-methyl-2,4(1H,3H)-pyrimidinedione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-[(2R,6S)-6-(Hydroxymethyl)-2-morpholinyl]-5-methyl-2,4(1H,3H)-pyrimidinedione
250mg
$ 1845.00

Total 9 raw suppliers

Chemical Property of 1-[(2R,6S)-6-(Hydroxymethyl)-2-morpholinyl]-5-methyl-2,4(1H,3H)-pyrimidinedione

Chemical Property:

PSA：96.35000
LogP:-1.34690
XLogP3:-2.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:241.10625597
Heavy Atom Count:17
Complexity:369

Purity/Quality:

97% ^*data from raw suppliers

1-[(2R,6S)-6-(Hydroxymethyl)-2-morpholinyl]-5-methyl-2,4(1H,3H)-pyrimidinedione ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CN(C(=O)NC1=O)C2CNCC(O2)CO
Isomeric SMILES:CC1=CN(C(=O)NC1=O)[C@H]2CNC[C@H](O2)CO
Uses 1-[(2R,6S)-6-(Hydroxymethyl)-2-morpholinyl]-5-methyl-2,4(1H,3H)-pyrimidinedione is used as a reactant in the synthesis of protected morpholino monomers and morpholinoglycine oligonucleotide.

Technology Process of 1-[(2R,6S)-6-(Hydroxymethyl)-2-morpholinyl]-5-methyl-2,4(1H,3H)-pyrimidinedione

There total 1 articles about 1-[(2R,6S)-6-(Hydroxymethyl)-2-morpholinyl]-5-methyl-2,4(1H,3H)-pyrimidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1463-10-1,642082-80-2
5-Methyluridine

: 179073-10-0
C₁₀H₁₅N₃O₄

Guidance literature:: 5-Methyluridine; With sodium periodate; triethylamine; In ethanol; water; for 2h; pH=8.5 - 9;

With sodium cyanoborohydride; In ethanol; water; for 1h;
DOI:10.3762/bjoc.10.115

Reference yield:

: 179073-10-0
C₁₀H₁₅N₃O₄

: 76-83-5
trityl chloride

: 914361-76-5
1-((2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; for 1h; pH=8.5 - 9;
DOI:10.3762/bjoc.10.115

Reference yield:

: 179073-10-0
C₁₀H₁₅N₃O₄

: 2-aminomethyl-4-trityl-6-(thymin-1-yl)morpholine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / N,N-dimethyl-formamide / 1 h / pH 8.5 - 9

2.1: triphenylphosphine; sodium azide; Bromotrichloromethane / N,N-dimethyl-formamide

3.1: triphenylphosphine; pyridine

3.2: 6 h

With pyridine; sodium azide; Bromotrichloromethane; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide;
DOI:10.3762/bjoc.10.115