(5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone

Base Information

• Chemical Name: (5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone
• CAS No.: 1132832-75-7
• Molecular Formula: C18H12BrFOS
• Molecular Weight: 375.261
• Hs Code.: 2934999090
• Mol file: 1132832-75-7.mol

Synonyms:(5-bromo-2-methyl-phenyl)-[5-(4-fluoro-phenyl)-thiophen-2-yl]-methanone;Methanone,(5-bromo-2-methylphenyl)(4-methoxyphenyl);(5-bromo-2-methylphenyl)(5-(4-fluorophenyl)-2-thienyl)methanone;5-Bromo-2-methyl-4'methoxybenzophenone;(5-Bromo-2-methyl-phenyl)-(4-methoxy-phenyl)-methanone;

Chemical Property of (5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone

Chemical Property:

• Boiling Point: 476.0±45.0 °C(Predicted)
• PSA: 45.31000
• Density: 1.448±0.06 g/cm3(Predicted)
• LogP: 5.85610
• Storage Temp.: 2-8°C(protect from light)
• Solubility.: DMSO (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

2-(5-Bromo-2-methylbenzoyl)-5-(4-fluorophenyl)thiophene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(5-Bromo-2-methylbenzoyl)-5-(4-fluorophenyl)thiophene is an intermediate in the preparation of Canagliflozin which is a sodium-dependent glucose co-transporter 2 inhibitor used in the treatment of type 2 diabetes.

Technology Process of (5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone

There total 13 articles about (5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.2%

2-(4-fluorophenyl)thiophene (58861-48-6) + 5-bromo-2-methylbenzoic acid (79669-49-1) → (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7)

Guidance literature:

5-bromo-2-methylbenzoic acid; With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide; at 20 - 25 ℃;

2-(4-fluorophenyl)thiophene; With aluminum (III) chloride; In dichloromethane; at 0 - 25 ℃; for 12.5h; Solvent; Reagent/catalyst;

Reference yield: 90.1%

2-(4-fluorophenyl)thiophene (58861-48-6) + 5-bromo-2-methylbenzoyl?chloride (21900-41-4) → (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; at -10 - 25 ℃; for 5.5h; Inert atmosphere;

Reference yield:

5-(4-fluorophenyl)thiophene-2-carbonyl chloride (918487-45-3) + para-bromotoluene (106-38-7) → (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7)

Guidance literature:

With iron(III) chloride; In dichloromethane; at 20 ℃; for 20h;

upstream raw materials:

2-(4-fluorophenyl)thiophene

5-bromo-2-methylbenzoyl?chloride

1-Bromo-4-fluorobenzene

5-bromo-2-methylbenzoic acid

Downstream raw materials:

3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl bromide

(1R,4R,5S,6R)-4,5,6-tris(benzyloxy)-3-(benzyloxymethyl)-1-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)cyclohex-2-enol

methyl 1-C-(3-{[5-(4-fluorophenyl)-2-thienyl]methyl}-4-methyl-phenyl)-D-glucopyranoside

canagliflozin