2-(4-FLUOROPHENYL)THIOPHENE

Base Information

• Chemical Name: 2-(4-FLUOROPHENYL)THIOPHENE
• CAS No.: 58861-48-6
• Molecular Formula: C10H7FS
• Molecular Weight: 178.23
• Hs Code.: 2934999090
• Mol file: 58861-48-6.mol

Synonyms:2-(4-Fluorophenyl)thiophene;

Chemical Property of 2-(4-FLUOROPHENYL)THIOPHENE

Chemical Property:

• Vapor Pressure: 0.031mmHg at 25°C
• Melting Point: 51.0 to 55.0 °C
• Refractive Index: 1.578
• Boiling Point: 252.316 °C at 760 mmHg
• Flash Point: 106.397 °C
• PSA: 28.24000
• Density: 1.201 g/cm³
• LogP: 3.55420
• Storage Temp.: 2-8°C(protect from light)
• Solubility.: soluble in Methanol

Purity/Quality:

98% ^*data from raw suppliers

2-(4-Fluorophenyl)-thiophene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(4-Fluorophenyl)-thiophene can be used to prepare Canagliflozin (C175190) as sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for treatment of type 2 diabetes mellitus.

Technology Process of 2-(4-FLUOROPHENYL)THIOPHENE

There total 49 articles about 2-(4-FLUOROPHENYL)THIOPHENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-bromothiophene (1003-09-4) + 4-fluoroboronic acid (1765-93-1) → 2-(4-fluorophenyl)thiophene (58861-48-6)

Guidance literature:

With Tedicyp; potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)); In xylene; at 130 ℃; for 20h;

DOI:10.1016/j.jorganchem.2003.07.005

Reference yield: 95.0%

2-bromothiophene (1003-09-4) + 4-flourophenylmagnesium bromide (352-13-6) → 2-(4-fluorophenyl)thiophene (58861-48-6)

Guidance literature:

2-bromothiophene; With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; In tetrahydrofuran; at 2 ℃; for 0.666667h;

4-flourophenylmagnesium bromide; In tetrahydrofuran; at 10 - 23 ℃; for 1.66667h;

With acetic acid; In tetrahydrofuran; water; at 7 ℃; for 0.75h;

Reference yield: 94.0%

2-Iodothiophene (3437-95-4,149762-92-5) + 4-fluoroboronic acid (1765-93-1) → 2-(4-fluorophenyl)thiophene (58861-48-6)

Guidance literature:

With potassium carbonate; In water; N,N-dimethyl-formamide; at 100 ℃; for 0.333333h; under 2585.81 Torr; Microwave irradiation;

DOI:10.1039/b814715a

upstream raw materials:

thiophene boronic acid

2-bromothiophene

4-fluoroboronic acid

4-Fluorothiophenol

Downstream raw materials:

(2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene)

5-(4-fluorophenyl)thiophene-2-carboxylic acid

2-butyl-5-(5-(4-fluorophenyl)thiophen-2-yl)furan

2-(4-fluorophenyl)-tetrahydrothiophene

Refernces

• 1、 Kundu, Abhishek,Dey, Dhananjay,Pal, Subhankar,Adhikari, Debashis. "Pyrazole-Mediated C-H Functionalization of Arene and Heteroarenes for Aryl-(Hetero)aryl Cross-Coupling Reactions". . p. 15665 - 15673. Retrieved 2021/11/16.
• 2、 Annes, Sesuraj Babiola,Ramesh, Subburethinam,Saravanan, Subramanian,Saritha, Rajendhiran. "Carbazole based Electron Donor Acceptor (EDA) catalysis for the synthesis of biaryl and aryl-heteroaryl compounds". . p. 2510 - 2515. Retrieved 2020/04/15.