1-Benzyl-1,6-diazaspiro[3.3]heptane oxalate

Base Information

• Chemical Name: 1-Benzyl-1,6-diazaspiro[3.3]heptane oxalate
• CAS No.: 1223573-43-0
• Molecular Formula: C14H18N2O4
• Molecular Weight: 278.30372
• Hs Code.: 2934999090
• Mol file: 1223573-43-0.mol

Synonyms:1-benzyl-1,6-diazaspiro[3.3]heptane,oxalic acid;

Chemical Property of 1-Benzyl-1,6-diazaspiro[3.3]heptane oxalate

Chemical Property:

• Melting Point: 179-181℃
• PSA: 89.87000
• LogP: 0.65660

Purity/Quality:

97% ^*data from raw suppliers

1-Benzyl-1,6-diazaspiro[3.3]heptaneHemioxalate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Benzyl-1,6-diazaspiro[3.3]heptane oxalate

There total 1 articles about 1-Benzyl-1,6-diazaspiro[3.3]heptane oxalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

1-benzyl-6-tosyl-1,6-diazaspiro[3.3]heptane (1223573-36-1) + oxalic acid (144-62-7,97993-78-7) → 1-(benzyl-1-aza-6-azoniaspiro[3.3]heptane) oxalate (1223573-43-0)

Guidance literature:

1-benzyl-6-tosyl-1,6-diazaspiro[3.3]heptane; With magnesium; In methanol; for 0.5h; Inert atmosphere;

oxalic acid; In ethanol;

DOI:10.1021/ol1003302

Reference yield:

tert-butyldicarbonate (34619-03-9) + 1-benzyl-1,6-diaza-spiro[3.3]heptane oxalate (1223573-43-0) → tert-butyl 1-benzyl-1,6-diazaspiro[3.3]heptane-6-carboxylate (1431868-59-5)

Guidance literature:

1-benzyl-1,6-diaza-spiro[3.3]heptane oxalate; With triethylamine; In methanol; for 0.0833333h;

tert-butyldicarbonate; In methanol; at 20 ℃;

Reference yield:

1-benzyl-1,6-diaza-spiro[3.3]heptane oxalate (1223573-43-0) → N-(2,4-dichlorobenzyl)-1-(4-fluorophenylsulfonyl)-1,6-diazaspiro[3.3]heptane-6-carboxamide (1431868-39-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triethylamine / methanol / 0.08 h

1.2: 20 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 48 h / 20 °C

3.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / 3.5 h / 20 °C

5.1: triethylamine / 1 h / 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; trifluoroacetic acid; In methanol; dichloromethane;

upstream raw materials:

1-benzyl-6-tosyl-1,6-diazaspiro[3.3]heptane

oxalic acid

Downstream raw materials:

1-(4-fluorophenylsulfonyl)-1,6-diazaspiro[3.3]heptane

N-(2,4-dichlorobenzyl)-1,6-diazaspiro[3.3]heptane-1-carboxamide

tert-butyl 1-(4-fluorophenylsulfonyl)-1,6-diazaspiro[3.3]heptane-6-carboxylate

N-(2,4-dichlorobenzyl)-1-(4-fluorophenylsulfonyl)-1,6-diazaspiro[3.3]heptane-6-carboxamide

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