Synonyms:hydron;oxalate;2-oxo-2-oxonioacetate
99% *data from raw suppliers
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Xn:Harmful;There total 2193 articles about 2-Oxo-2-oxonioacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
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The study presents an eco-friendly and cost-effective method for converting dithioacetals to carbonyl compounds using oxalic acid as a catalyst. Dithioacetals, which are stable functional groups used as acyl anion equivalents and protecting groups in organic synthesis, are typically challenging to convert into carbonyl compounds due to their stability. Traditional methods often involve toxic heavy metal salts like HgCl2, which pose environmental and disposal challenges. In this research, oxalic acid catalyzes the hydrolysis of dithioacetals in the presence of acetals such as dimethoxymethane (DMM) or diethoxymethane (DEM), yielding carbonyl compounds and bis(dodecylthio)methane. The reaction is effective for both aldehydes and ketones, with nitromethane as the preferred solvent. The study highlights the use of oxalic acid as a green alternative to toxic reagents, offering high yields and recyclability of dithioacetals. The proposed mechanism involves protonation of the acetal, nucleophilic attacks by sulfur atoms, and subsequent eliminations leading to the formation of carbonyl compounds.
The research focuses on the practical syntheses of the adhesion molecule inhibitor ER-49890 and its stereoisomer. The study reports improved synthetic routes for both the anti- and syn-isomers, with a key innovation being the stereoselective synthesis of the anti-(3-azabicyclo[3.3.1]non-9-yl)acetic acid side chain (anti-12) using Pd/C hydrogenation in the presence of HCl. The syn-isomer (syn-12) was obtained through a crystallization process as its oxalic acid salt from a mixture of anti- and syn-isomers. The 10H-pyrazino[2,3-b][1,4]benzothiazine core (7) was prepared from commercially available 4-chloro-3-nitrobenzyl alcohol (13) in a four-step process with good yield. The experiments involved various reactants, including sodium sulfide, 2,3-dichloropyrazine, triphenylphosphine, and iron powder, among others, and employed techniques such as HPLC, IR spectroscopy, NMR spectroscopy, and mass spectrometry for analysis. The study also detailed the effects of different solvents and additives on the hydrogenation process, leading to a selective synthesis of anti-12 with improved yields.
The study focuses on the synthesis and properties of dimetallic complexes based on a new oxalamidine-derived ligand system with pendant pyridine functionality. The researchers used sterically hindered bis(imidoyl)chlorides of oxalic acid and picolylamine to create conformationally locked oxalic acid-derived amidines with pendant pyridine functional groups. These amidines served as multivalent ligands for the formation of heterodimetallic and homodimetallic diazadiene complexes, which are of interest due to their potential cooperative effects in catalysis, intramolecular electron transfer reactions, and magnetic interactions. The study also explores the coordination chemistry of these ligands with various metals, including molybdenum, cobalt, and copper, to understand their conformational restrictions and the role of intramolecular hydrogen bonding in their structure and reactivity. The synthesized complexes were characterized using various analytical techniques, including NMR, IR, and X-ray crystallography.
The research focuses on the development of a mild, racemization-free method for cleaving ketone SAMP-hydrazones using oxalic acid. The purpose of this study was to achieve high efficiency in asymmetric synthesis by developing a non-stoichiometric method that allows for the recycling of chiral reagents, specifically the chiral auxiliary SAMP. The researchers concluded that the use of a saturated aqueous solution of oxalic acid for the cleavage of ketone SAMP-hydrazones resulted in the corresponding ketones with excellent yields and high enantiomeric purity (90 - 99%). The chiral auxiliary SAMP could be recovered from the aqueous phase with good yield (85%) and unchanged enantiomeric purity. This method is compatible with functionalities sensitive to oxidative cleavage conditions or strong acids, and it avoids the formation of carcinogenic nitrosoamine by-products, which occur in ozonolysis, and eliminates the need for toxic methylating reagents used in the salt method. The chemicals used in the process include oxalic acid, ketone SAMP-hydrazones, and various ketones as substrates for the cleavage reaction.
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