2,2,2-Trifluoroacetophenone-4-boronic acid pinacol ester

Base Information

Chemical Name:2,2,2-Trifluoroacetophenone-4-boronic acid pinacol ester
CAS No.:1004294-77-2
Molecular Formula:C14H16BF3O3
Molecular Weight:300.085
Hs Code.:
Mol file:1004294-77-2.mol

Synonyms:2,2,2-Trifluoroacetophenone-4-boronic acid pinacol ester;2,2,2-trifluoro-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanone

Suppliers and Price of 2,2,2-Trifluoroacetophenone-4-boronic acid pinacol ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2,2,2-Trifluoroacetophenone-4-boronicAcidPinacolEster
50mg
$ 90.00

Crysdot
2,2,2-Trifluoro-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanone 95+%
1g
$ 456.00

Chemenu
2,2,2-Trifluoro-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanone 95%+
1g
$ 273.00

American Custom Chemicals Corporation
2,2,2-TRIFLUOROACETOPHENONE-4-BORONIC ACID PINACOL ESTER 95.00%
1G
$ 401.10

Alichem
2,2,2-Trifluoro-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanone
1g
$ 456.00

Total 14 raw suppliers

Chemical Property of 2,2,2-Trifluoroacetophenone-4-boronic acid pinacol ester

Chemical Property:

Boiling Point:343.9±42.0 °C(Predicted)
PSA：35.53000
Density:1.20±0.1 g/cm3(Predicted)
LogP:2.73080
Storage Temp.:2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2,2,2-Trifluoroacetophenone-4-boronicAcidPinacolEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 2,2,2-Trifluoroacetophenone-4-boronic Acid Pinacol Ester is used as a reactant in the synthesis of trifluoroacetophenone-linked nucleotides and DNA.

Technology Process of 2,2,2-Trifluoroacetophenone-4-boronic acid pinacol ester

There total 2 articles about 2,2,2-Trifluoroacetophenone-4-boronic acid pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.1%

: 16184-89-7
4'-bromo-2,2,2-trifluoroacetophenone

: 73183-34-3
bis(pinacol)diborane

: 1004294-77-2
2,2,2-trifluoro-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethan-1-one

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium acetate; In N,N-dimethyl-formamide; at 90 ℃; for 12h; Reagent/catalyst; Temperature; Solvent; Inert atmosphere;

Reference yield: 71.0%

: 1426082-73-6
2,2,2-trifluoro-1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-ethanol

: 1004294-77-2
2,2,2-trifluoro-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethan-1-one

Guidance literature:: With 9-azabicyclo[3.3.1]nonan-3-one N-oxyl oxide; oxygen; acetic acid; sodium nitrite; at 20 ℃; for 18h; under 760.051 Torr; chemoselective reaction;
DOI:10.1002/adsc.201500131

Reference yield: 88.0%

: 1004294-77-2
2,2,2-trifluoro-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethan-1-one

: 5-iodo-2'-deoxycytidine monophosphate

: 5-[4-(trifluoroacetyl)phenyl]-2′-deoxycytidine 5′-O-phosphate

Guidance literature:: With trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; potassium carbonate; In water; acetonitrile; at 80 ℃; for 4h; Inert atmosphere;
DOI:10.1021/acs.joc.7b01920