Technology Process of Tert-butyl 2-bromo-5-methoxyphenylcarbamate
There total 2 articles about Tert-butyl 2-bromo-5-methoxyphenylcarbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-bromo-5-methoxyaniline;
With
sodium hexamethyldisilazane;
In
tetrahydrofuran;
at 0 ℃;
for 0.25h;
Inert atmosphere;
di-tert-butyl dicarbonate;
In
tetrahydrofuran;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogenchloride; iron / ethanol / 24 h / Reflux
2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
2.2: 20 °C
With
hydrogenchloride; sodium hexamethyldisilazane; iron;
In
tetrahydrofuran; ethanol;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tert.-butyl lithium / diethyl ether; pentane / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: hydrogenchloride / 1,4-dioxane / Inert atmosphere
3.1: tert.-butylnitrite; trimethylsilylazide / acetonitrile / 1.5 h / 0 - 20 °C / Inert atmosphere
4.1: bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]} / toluene / 16 h / 120 °C / Schlenk technique; Inert atmosphere; Sealed tube
With
hydrogenchloride; tert.-butylnitrite; bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]}; trimethylsilylazide; tert.-butyl lithium;
In
1,4-dioxane; diethyl ether; toluene; acetonitrile; pentane;
DOI:10.1021/jacs.7b01833
