22246-83-9

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
2H-1-Benzazepin-2-one, 1,3,4,5-tetrahydro-8-methoxyis utilized as a chemical entity in pharmaceutical research and drug development for its potential applications in treating a range of medical conditions. Its unique structure and the presence of the methoxy group may contribute to its pharmacological activity, making it a valuable compound for the discovery and development of new therapeutic agents.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2H-1-Benzazepin-2-one, 1,3,4,5-tetrahydro-8-methoxyis employed as a starting material or a scaffold for the synthesis of new compounds with potential therapeutic effects. Its chemical properties and reactivity can be leveraged to create derivatives that may exhibit improved pharmacological profiles, such as enhanced potency, selectivity, or reduced side effects.
Used in Drug Discovery:
2H-1-Benzazepin-2-one, 1,3,4,5-tetrahydro-8-methoxyis used in drug discovery as a lead compound. Its structural features can be optimized through medicinal chemistry techniques to identify new drug candidates with the desired biological activity. 2H-1-Benzazepin-2-one, 1,3,4,5-tetrahydro-8-methoxy-'s potential to interact with specific biological targets makes it a valuable asset in the search for novel therapeutic agents.
Used in Preclinical Studies:
In preclinical studies, 2H-1-Benzazepin-2-one, 1,3,4,5-tetrahydro-8-methoxyis used to evaluate its safety, efficacy, and pharmacokinetic properties. These studies are crucial for understanding how the compound behaves in biological systems and for assessing its potential as a viable drug candidate before it can proceed to clinical trials.

InChI:InChI=1/C11H13NO2/c1-14-9-6-5-8-3-2-4-11(13)12-10(8)7-9/h5-7H,2-4H2,1H3,(H,12,13)

Upstream product

• 99833-87-1 7-methoxy-1-tetralone O-tosyloxime 
• 20175-97-7 7-methoxy-3,4-dihydronaphthalen-1(2H)-one oxime 
• 6836-19-7 7-Methoxy-1-tetralone 
• 7664-93-9 sulfuric acid 
• 887354-63-4 C₁₈H₁₉NO₃S 
• 169303-80-4 tert-butyl (2-bromo-5-methoxyphenyl)carbamate 

Downstream Products

• 17422-43-4 8-methoxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine 
• 250131-91-0 (3-benzyloxycarbonylamino-8-methoxy-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl)-acetic acid tert-butyl ester 
• 187601-84-9 8-methoxy-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one 
• 200010-54-4 8-Methoxy-1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepine 
• 187601-82-7 8-methoxy-1-tosyl-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one 
• 200010-59-9 8-Methoxy-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-benzo[b]azepine-4,5-dione 4-oxime 
• 200010-60-2 8-Methoxy-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-benzo[b]azepine-4,5-dione 4-(O-methyl-oxime) 
• 200010-64-6 N-[8-Methoxy-5-oxo-1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-4-yl]-acetamide 
• 200010-72-6 N-[8-Methoxy-5-oxo-1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-4-yl]-propionamide 

Relevant academic research and scientific papers

Benzo Annulenes as Antiviral Agents

The present disclosure is concerned with benzo annulene compounds that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, chikungunya, Venezuelan equine encephalitis, dengue, influenza, and zika, usi

Rh2(II)-Catalyzed Ring Expansion of Cyclobutanol-Substituted Aryl Azides to Access Medium-Sized N-Heterocycles

A new reactivity pattern of Rh2(II)-N-arylnitrenes was discovered that facilitates the synthesis of medium-sized N-heterocycles from ortho-cyclobutanol-substituted aryl azides. The key ring-expansion step of the catalytic cycle is both chemosel

CARBOXY X RHODAMINE ANALOGS

The present invention provides novel fluorescent dyes and kits containing the same, which are useful for labeling a wide variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes f

The application of the schmidt reaction and beckmann rearrangement to the synthesis of bicyclic lactams: Some mechanistic considerations

The syntheses of some methoxy-substituted bicyclic lactams, of the types 3 and 4, are reported employing two different conditions for the Schmidt reaction of appropriate ketones and employing two different conditions for the Beckmann rearrangement of the corresponding ketoximes. The alkyl to aryl migration ratios of the reactions were determined by high-performance liquid chromatography analysis of the reactions. The mechanisms of the reactions reported are discussed, some limitations of the reported mechanisms identified, and an alternative mechanism proposed in light of the outcomes of the various reactions. Application of the Schmidt reaction and Beckmann rearrangement was used for the synthesis of some chloro bicyclic lactams, of the types 3 and 4. CSIRO 2010.

FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS

The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, and A5, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.

TETRAHYDRO-PYRIDOAZEPIN-8-ONES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA

Compounds of formula 1 are disclosed, wherein G, D, A, Q, Y, Z, and R1 through R10 are defined in the specification. Also provided are descriptions of processes for preparing compounds of formula 1, intermediates used in making the same, and pharmaceutical compositions containing such compounds and their use in the treatment of central nervous system disorders and other disorders.

Substituted 1-benzazepines and derivatives thereof

This invention relates to substituted 1-benzazepines and derivatives thereof useful as antibacterial agents, to compositions, including pharmaceutical compositions, comprising such compounds, to processes for making these compounds and to methods of using these compounds for killing bacteria or inhibiting bacterial growth.

Synthesis of paullones with aminoalkyl side chains

Paullones 3 and 4 with aminoalkyl side chains in 2- or 3-position were synthesized as derivatives of kenpaullone 1. Both 3 and 4 showed the characteristic CDK1-inhibitory activity of the paullones and a modest antiproliferative activity on cultured human tumor cell lines. Hence, 3 and 4 appear to be suitable tools for affinity studies directed to find additional intracellular paullone targets.

Novel benzo-fused lactam scaffolds as factor Xa inhibitors

Rigid benzolactam P3-P2 dipeptide mimics were designed and prepared as potential inhibitors of blood coagulation factor Xa. Methoxy substitution of the tetrahydrobenzazepinone scaffold led to potent and selective inhibitors. The synt

Azabenzocycloheptenones. Part 20. Synthesis and utilisation of 4-amino-1,2,3,4-tetrahydro-1(1H)-benzazepines

1,2,3,4-Tetrahydro-6- and -7-methoxy-4-oxo-1-(p-tolylsulfonyl)quinolines 3 (R = tosyl, X = 6- and 7-OMe) and 1-ethoxycarbonylmethyl-1,2,3,4-tetrahydro-7-methoxy-4-oxoquinoline3 (R = CH2CO2Et, X = 7-OMe) have been ring-expanded in two