Cyclopropanesulfinic acid, sodium salt

Base Information

• Chemical Name: Cyclopropanesulfinic acid, sodium salt
• CAS No.: 910209-21-1
• Molecular Formula: C3H5NaO2S
• Molecular Weight: 128.127
• Hs Code.: 2930909090
• Mol file: 910209-21-1.mol

Synonyms:CYCLOPROPANESULFINIC ACID, SODIUM SALT;Sodium Cyclopropanesulfinate

Chemical Property of Cyclopropanesulfinic acid, sodium salt

Chemical Property:

• Melting Point: 245-248°C
• PSA: 59.34000
• LogP: 0.89360
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

Sodium Cyclopropanesulfinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Sodium Cyclopropanesulfinate is a general chemical reagent used in the synthesis of AMG 232 (A576560), a potent MDM2-P53 inhibitor for use as an anti-tumor agent.

Technology Process of Cyclopropanesulfinic acid, sodium salt

There total 1 articles about Cyclopropanesulfinic acid, sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

cyclopropanesulfonyl chloride (139631-62-2) → sodium cyclopropylsulfinate (910209-21-1)

Guidance literature:

With anhydrous sodium carbonate; anhydrous sodium sulphite; In water monomer; at 50 ℃; for 2h;

DOI:10.1016/j.tetlet.2014.04.111

Reference yield: 99.0%

sodium cyclopropylsulfinate (910209-21-1) + 2-fluro-4-iodoaniline (29632-74-4) → C9H10FNO2S (1147558-09-5)

Guidance literature:

With N,N`-dimethylethylenediamine; copper (I) trifluoromethane sulfonate benzene; In dimethyl sulfoxide; at 120 ℃; for 16h;

Reference yield: 98.0%

sodium cyclopropylsulfinate (910209-21-1) + Benzyl bromoacetate (5437-45-6) → benzyl 2-(cyclopropylsulfonyl)acetate

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

cyclopropanesulfonyl chloride

Downstream raw materials:

C₉H₁₀FNO₂S

4-(cyclopropylsulfonyl)-1H-pyrazolo[3,4-b]pyridine

methyl 3-((1R)-3-(benzyloxy)cyclopentyl)-2-(4-(cyclopropylsulfonyl)-1H-indazol-1-yl)propanoate

6-(cyclopropylsulfonyl)-2-(2'-fluorobiphenyl-4-yl)-1H-benzimidazole