5-Amino-2,4-di-tert-butylphenol

Base Information

• Chemical Name: 5-Amino-2,4-di-tert-butylphenol
• CAS No.: 873055-58-4
• Molecular Formula: C14H23NO
• Molecular Weight: 221.343
• Hs Code.: 2922299090
• Mol file: 873055-58-4.mol

Synonyms:5-AMino-2,4-di-tert-butylphenol

Chemical Property of 5-Amino-2,4-di-tert-butylphenol

Chemical Property:

• Boiling Point: 319.7±30.0 °C(Predicted)
• PKA: 11.63±0.23(Predicted)
• PSA: 46.25000
• Density: 0.990±0.06 g/cm3(Predicted)
• LogP: 4.15060
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98% ^*data from raw suppliers

5-Amino-2,4-di-tert-butylphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Amino-2,4-di-tert-butylphenol is an intermediate used in the preparation of ivacaftor via condensation of oxo dihydroquinoline carboxylic acid with amino ditert butylphenol.

Technology Process of 5-Amino-2,4-di-tert-butylphenol

There total 10 articles about 5-Amino-2,4-di-tert-butylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,4-di-tert-butyl-5-nitro-phenol (873055-57-3) → 5-amino-2-4-di-tert-butyl-phenol (873055-58-4)

Guidance literature:

With ammonium formate; 5%-palladium/activated carbon; In ethanol; for 2h; Heating / reflux;

Reference yield: 89.0%

N-(2,4-di-tert-butyl-5-hydroxyphenyl)acetamide → 5-amino-2-4-di-tert-butyl-phenol (873055-58-4)

Guidance literature:

With hydrogenchloride; In ethanol; water; for 6h; Reflux;

DOI:10.1002/jhet.2931

Reference yield:

2,4-di-tert-butyl-5-nitro-phenol (873055-57-3) + pyrographite (7440-44-0) → 5-amino-2-4-di-tert-butyl-phenol (873055-58-4)

Guidance literature:

With ammonium formate; In ethanol;

upstream raw materials:

2,4-di-tert-butyl-5-nitro-phenol

pyrographite

carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester

carbonic acid 2,4-di-tert-butyl-phenyl ester methyl ester

Downstream raw materials:

2,4-di-tert-butyl-6-(N-methylamino)phenol

5-amino-2,4-di-tert-butylphenyl methyl carbonate

N-(2,4-di-tert-butyl-5-hydroxyphenyl)-7-ethyl-4-oxo-1,4-dihydropyrrolo[1,2-a]pyrimidine-3-carboxamide

N-(2,4-di-tert-butyl-5-hydroxyphenyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxamide

Refernces

• 1、 -. "METHODS OF TREATMENT FOR CYSTIC FIBROSIS". Paragraph 00232. . Retrieved 2020/12/11.
• 2、 -. "METHODS OF TREATMENT FOR CYSTIC FIBROSIS". Paragraph 00151. . Retrieved 2019/02/06.