5-(2-cyclopropyl-1-(3-fluorophenyl)-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate

Base Information

Chemical Name:5-(2-cyclopropyl-1-(3-fluorophenyl)-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate
CAS No.:1391194-39-0
Molecular Formula:C₂₀H₂₀FNO₃S
Molecular Weight:373.448
Hs Code.:
Mol file:1391194-39-0.mol

Synonyms:5-(2-cyclopropyl-1-(3-fluorophenyl)-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate;Prasugrel IMpurity 2;Prasugrel IMpurity II

Suppliers and Price of 5-(2-cyclopropyl-1-(3-fluorophenyl)-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
5-(2-Cyclopropyl-1-(3-fluorophenyl)-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-ylacetate 95+%
100mg
$ 2232.00

Crysdot
5-(2-Cyclopropyl-1-(3-fluorophenyl)-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-ylacetate 95+%
50mg
$ 1340.00

Total 24 raw suppliers

Chemical Property of 5-(2-cyclopropyl-1-(3-fluorophenyl)-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate

Chemical Property:

Boiling Point:495.5±45.0 °C(Predicted)
PKA:3.89±0.20(Predicted)
PSA：74.85000
Density:1.347±0.06 g/cm3(Predicted)
LogP:3.82890

Purity/Quality:

99% ^*data from raw suppliers

5-(2-Cyclopropyl-1-(3-fluorophenyl)-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-ylacetate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 3-Fluoro Prasugrel is an impurity and a related compound of Prasugrel, a novel antiplatelet agent.

Technology Process of 5-(2-cyclopropyl-1-(3-fluorophenyl)-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate

There total 2 articles about 5-(2-cyclopropyl-1-(3-fluorophenyl)-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-(2-cyclopropyl-1-(3-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one

: 108-24-7
acetic anhydride

: 1391194-39-0
5-(2-cyclopropyl-1-(3-fluorophenyl)-2-oxoethyl)-4,5,6,7-tetrahydrothieno [3,2-c]pyridin-2-yl acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 5 ℃; for 1h; Inert atmosphere;
DOI:10.14233/ajchem.2013.14606

Reference yield:

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

: 1359829-72-3
2-bromo-1-cyclopropyl-2-(3-fluorophenyl)ethanone

: 1391194-39-0
5-(2-cyclopropyl-1-(3-fluorophenyl)-2-oxoethyl)-4,5,6,7-tetrahydrothieno [3,2-c]pyridin-2-yl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 4 h / 0 - 5 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 0 - 5 °C / Inert atmosphere

With potassium carbonate; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.14233/ajchem.2013.14606