Prasugrel

Base Information

• Chemical Name: Prasugrel
• CAS No.: 115473-15-9
• Molecular Formula: C7H10ClNOS
• Molecular Weight: 191.681
• Hs Code.: 29349990
• Mol file: 115473-15-9.mol

Synonyms:2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine.Hydrochloride;Thieno[3,2-c]pyridin-2(4H)-one,5,6,7,7a-tetrahydro-, hydrochloride (1:1);

Chemical Property of Prasugrel

Chemical Property:

• Appearance/Colour: Cream solid
• Melting Point: 210 °C
• Boiling Point: 364.3 °C at 760 mmHg
• Flash Point: 174.1 °C
• PSA: 54.40000
• LogP: 1.67890
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility.: DMSO, Methanol, Water

Purity/Quality:

99% ^*data from raw suppliers

5,6,7,7a-Tetrahydrothieno[3,2-c]pyridinoneHydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Solifenacin intermediate An intermediate in the synthesis of Prasugrel (P701150).

Technology Process of Prasugrel

There total 6 articles about Prasugrel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-triphenylmethyl-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine (109904-26-9) → 5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride (115473-15-9)

Guidance literature:

With hydrogenchloride; In water; acetone; at 25 - 50 ℃; for 1h;

Reference yield: 86.1%

N-trityl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine (109904-25-8) → 5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride (115473-15-9)

Guidance literature:

N-trityl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine; With N,N,N,N,-tetramethylethylenediamine; n-hexyllithium; In toluene; at 0 ℃; Large scale;

With boric acid tributyl ester; In toluene; at 0 ℃; for 1h; Further stages; Large scale;

Reference yield:

2-methoxy-5-tert-butoxycarbonyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine → 5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride (115473-15-9)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 12h;

upstream raw materials:

5-triphenylmethyl-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

N-trityl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine

[2-(2-thyenyl)ethyl]amine

Downstream raw materials:

5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one

prasugel

5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydro thieno[3,2-c] pyridine hydrochloride

2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

Refernces

• 1、 -. "PROCESS FOR THE PREPARATION OF HIGH-PURITY PRASUGREL". Page/Page column 13. . Retrieved 2018/04/11.
• 2、 -. "AN IMPROVED PROCESS FOR THE PREPARATION OF PRASUGREL HYDROCHLORIDE AND ITS INTERMEDIATES". Page/Page column 20. . Retrieved 2012/01/14.