5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine

Base Information

• Chemical Name: 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine
• CAS No.: 1180132-17-5
• Molecular Formula: C12H20N4
• Molecular Weight: 220.318
• Hs Code.: 2933990090
• Mol file: 1180132-17-5.mol

Synonyms:5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-ylamine;5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-amine;

Chemical Property of 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine

Chemical Property:

• Boiling Point: 362℃
• PKA: 7.71±0.10(Predicted)
• Flash Point: 173℃
• PSA: 46.12000
• Density: 1.101
• LogP: 0.60720
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98% ^*data from raw suppliers

5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine is a useful research chemical.

Technology Process of 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine

There total 23 articles about 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-ethylpiperazine (5308-25-8) + 2-chloro-5-(chloromethyl)pyridine (70258-18-3) → 5-((4-ethylpiperazin-1-yl)methyl)-6-methylpyridin-2-amine (1180132-17-5)

Guidance literature:

at 60 - 70 ℃; for 2h; Time; Green chemistry;

Reference yield: 91.0%

4-ethylpiperazine (5308-25-8) + 6-amino-3-pyridinecarbaldehyde (69879-22-7) → 5-((4-ethylpiperazin-1-yl)methyl)-6-methylpyridin-2-amine (1180132-17-5)

Guidance literature:

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 10h;

Reference yield: 91.0%

(6-aminopyridin-3-yl)(4-ethylpiperazin-1-yl)methanone → 5-((4-ethylpiperazin-1-yl)methyl)-6-methylpyridin-2-amine (1180132-17-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -10 - 20 ℃; for 2h;

upstream raw materials:

1-((6-bromopyridin-3-yl)methyl)-4-ethylpiperazine

4-ethylpiperazine

6-bromonicotinaldehyde

6-nitronicotinic acid

Downstream raw materials:

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

LY2835219