LY2835219

Base Information

Chemical Name:LY2835219
CAS No.:1231929-97-7
Molecular Formula:C27H32F2N8
Molecular Weight:506.601
Hs Code.:
Mol file:1231929-97-7.mol

Synonyms:N-[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine;2-Pyrimidinamine,N-[5-[(4-ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl];LY2835219;[5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-[5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-3H-benzoimidazol-5-yl)-pyrimidin-2-yl]-amine;Bemaciclib;CS-1230;

Suppliers and Price of LY2835219

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Abemaciclib
50mg
$ 95.00

DC Chemicals
LY2835219freebase(Abemaciclib) >99%
1 g
$ 1000.00

DC Chemicals
LY2835219freebase(Abemaciclib) >99%
100 mg
$ 250.00

Crysdot
Abemaciclib,LY2835219 98+%
100mg
$ 228.00

ChemScene
Abemaciclib 99.69%
10mg
$ 90.00

ChemScene
Abemaciclib 99.69%
5mg
$ 60.00

ChemScene
Abemaciclib 99.69%
50mg
$ 120.00

ChemScene
Abemaciclib 99.69%
100mg
$ 150.00

ChemScene
Abemaciclib 99.69%
200mg
$ 190.00

ChemScene
Abemaciclib 99.69%
500mg
$ 350.00

Total 115 raw suppliers

Chemical Property of LY2835219

Chemical Property:

Boiling Point:689.3±65.0 °C(Predicted)
PKA:7.69±0.10(Predicted)
PSA：75.00000
Density:1.32±0.1 g/cm3(Predicted)
LogP:4.88570
Solubility.:insoluble in H2O; ≥4.83 mg/mL in DMSO with gentle warming and ultrasonic; ≥6.34 mg/mL in EtOH with gentle warming

Purity/Quality:

99% ,99.9%, ^*data from raw suppliers

Abemaciclib ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of LY2835219

There total 25 articles about LY2835219 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.8%

: 6-(3-N,N-dimethylamino-2-fluoro-2-acrylketone-1-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzimidazole

: N-[5-(4-ethylpiperazine-1-yl-methyl)pyridine-2-yl]guanidine nitrate

: 1231929-97-7
N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

Guidance literature:: N-[5-(4-ethylpiperazine-1-yl-methyl)pyridine-2-yl]guanidine nitrate; With sulfuric acid; sodium methylate; In methanol; N,N-dimethyl-formamide; at 30 - 35 ℃; for 2h;

6-(3-N,N-dimethylamino-2-fluoro-2-acrylketone-1-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzimidazole; at 80 - 85 ℃; for 7h;

Reference yield: 82.85%

: 1180132-17-5
5-((4-ethylpiperazin-1-yl)methyl)-6-methylpyridin-2-amine

: 1231930-33-8
6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

: 1231929-97-7
N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

Guidance literature:: With palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; at 98 - 100 ℃; Inert atmosphere;