4-hydroxy-4-(5-(pyrimidin-2-yl)pyridine-2-yl) cyclohexanone

Base Information

• Chemical Name: 4-hydroxy-4-(5-(pyrimidin-2-yl)pyridine-2-yl) cyclohexanone
• CAS No.: 857651-06-0
• Molecular Formula: C15H15N3O2
• Molecular Weight: 269.303
• Mol file: 857651-06-0.mol

Synonyms:4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexanone;

Chemical Property of 4-hydroxy-4-(5-(pyrimidin-2-yl)pyridine-2-yl) cyclohexanone

Chemical Property:

• PSA: 75.97000
• LogP: 1.86930

Purity/Quality:

97% ^*data from raw suppliers

Cyclohexanone,4-hydroxy-4-[5-(2-pyrimidinyl)-2-pyridinyl]- ^*data from reagent suppliers

Safty Information:

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Technology Process of 4-hydroxy-4-(5-(pyrimidin-2-yl)pyridine-2-yl) cyclohexanone

There total 4 articles about 4-hydroxy-4-(5-(pyrimidin-2-yl)pyridine-2-yl) cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-(5-pyrimidin-2-ylpyridin-2-yl)-1,4-dioxaspiro[4.5]decan-8-ol (857651-05-9) → 4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexanone (857651-06-0)

Guidance literature:

8-(5-pyrimidin-2-ylpyridin-2-yl)-1,4-dioxaspiro[4.5]decan-8-ol; With hydrogenchloride; water; In tetrahydrofuran; for 1h;

With sodium carbonate; In tetrahydrofuran; water; pH=8 - 9;

Reference yield:

8-(5-bromopyridin-2-yl)-1,4-dioxaspiro[4.5]decan-8-ol (708274-37-7) → 4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexanone (857651-06-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 3.67 h / 25 °C / Inert atmosphere

1.2: 25 °C / Inert atmosphere

2.1: hydrogenchloride / tetrahydrofuran; water / 1 h / 20 - 25 °C

With hydrogenchloride; isopropylmagnesium chloride; In tetrahydrofuran; water;

DOI:10.1021/ml200199c

Reference yield:

2,5-dibromopyridine (624-28-2) → 4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexanone (857651-06-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / toluene / 2.5 h / -78 °C

1.2: -78 - 20 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 3.67 h / 25 °C / Inert atmosphere

2.2: 25 °C / Inert atmosphere

3.1: hydrogenchloride / tetrahydrofuran; water / 1 h / 20 - 25 °C

With hydrogenchloride; n-butyllithium; isopropylmagnesium chloride; In tetrahydrofuran; water; toluene;

DOI:10.1021/ml200199c

upstream raw materials:

8-(5-pyrimidin-2-ylpyridin-2-yl)-1,4-dioxaspiro[4.5]decan-8-ol

2,5-dibromopyridine

cyclohexanedione monoethylene ketal

8-(5-bromopyridin-2-yl)-1,4-dioxaspiro[4.5]decan-8-ol

Downstream raw materials:

PF-4136309

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