Technology Process of N-[2-[(3S)-3-[[4-hydroxy-4-(5-pyrimidin-2-ylpyridin-2-yl)cyclohexyl]amino]pyrrolidin-1-yl]-2-oxoethyl]-3-(trifluoromethyl)benzamide
There total 6 articles about N-[2-[(3S)-3-[[4-hydroxy-4-(5-pyrimidin-2-ylpyridin-2-yl)cyclohexyl]amino]pyrrolidin-1-yl]-2-oxoethyl]-3-(trifluoromethyl)benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexanone; (S)-N-{2-[3-aminopyrrolidin-1-yl]-2-oxoethyl}-3-(trifluoromethyl)benzamide hydrochloride;
With
triethylamine;
In
2-methyl-propan-1-ol;
for 0.5h;
Cooling with ice;
With
sodium tris(acetoxy)borohydride;
In
2-methyl-propan-1-ol;
at 20 ℃;
for 4h;
DOI:10.1021/ml200199c
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / toluene / 2.5 h / -78 °C
1.2: -78 - 20 °C
2.1: isopropylmagnesium chloride / tetrahydrofuran / 3.67 h / 25 °C / Inert atmosphere
2.2: 25 °C / Inert atmosphere
3.1: hydrogenchloride / tetrahydrofuran; water / 1 h / 20 - 25 °C
4.1: triethylamine / 2-methyl-propan-1-ol / 0.5 h / Cooling with ice
4.2: 4 h / 20 °C
With
hydrogenchloride; n-butyllithium; isopropylmagnesium chloride; triethylamine;
In
tetrahydrofuran; 2-methyl-propan-1-ol; water; toluene;
DOI:10.1021/ml200199c
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / toluene / 2.5 h / -78 °C
1.2: -78 - 20 °C
2.1: isopropylmagnesium chloride / tetrahydrofuran / 3.67 h / 25 °C / Inert atmosphere
2.2: 25 °C / Inert atmosphere
3.1: hydrogenchloride / tetrahydrofuran; water / 1 h / 20 - 25 °C
4.1: triethylamine / 2-methyl-propan-1-ol / 0.5 h / Cooling with ice
4.2: 4 h / 20 °C
With
hydrogenchloride; n-butyllithium; isopropylmagnesium chloride; triethylamine;
In
tetrahydrofuran; 2-methyl-propan-1-ol; water; toluene;
DOI:10.1021/ml200199c
