3-aminopyridin-4-ol hydrochloride

Base Information

• Chemical Name: 3-aminopyridin-4-ol hydrochloride
• CAS No.: 120256-13-5
• Molecular Formula: C₅H₆N₂O*ClH
• Molecular Weight: 146.576
• Hs Code.: 2933399090
• Mol file: 120256-13-5.mol

Synonyms:3-aminopyridin-4-ol hydrochloride

Chemical Property of 3-aminopyridin-4-ol hydrochloride

Chemical Property:

• Melting Point: 224-226℃
• PSA: 59.14000
• LogP: 1.75260

Purity/Quality:

98%Min ^*data from raw suppliers

3-Amino-pyridin-4-olhydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-aminopyridin-4-ol hydrochloride

There total 2 articles about 3-aminopyridin-4-ol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.77%

4-hydroxy-3-nitropyridine (5435-54-1) → 3-aminopyridin-4-ol hydrochloric acid (120256-13-5,128065-50-9)

Guidance literature:

4-hydroxy-3-nitropyridine; With palladium on activated charcoal; hydrogen; In methanol; N,N-dimethyl-formamide; at 15 ℃; for 4h; under 1292.9 - 2068.65 Torr;

With hydrogenchloride; In methanol;

Reference yield: 72.0%

3-nitro-4(1H)-pyridinone (15590-90-6) → 3-aminopyridin-4(1H)-one hydrochloride (128065-50-9,120256-13-5)

Guidance literature:

With hydrogenchloride; iron; for 1.5h; Heating;

Reference yield: 82.0%

3-amino-4-hydroxypyridine dihydrochloride (58671-00-4,120256-13-5,143458-65-5) + 4-nitro-benzoyl chloride (122-04-3) → 4-nitro-benzoic acid-(4-hydroxy-[3]pyridylamide) (99970-63-5)

Guidance literature:

With pyridine; at 10 ℃;

upstream raw materials:

4-hydroxy-3-nitropyridine

3-nitro-4(1H)-pyridinone

Downstream raw materials:

3-aminopyridine-4(1H)-thione

4-nitro-benzoic acid-(4-hydroxy-[3]pyridylamide)

N-(4-Hydroxy-pyridin-3-yl)-3-nitro-benzamide

2-(4-nitro-phenyl)-oxazolo[4,5-c]pyridine

Refernces

• 1、 Okoro. "Synthesis of new triaza and tetraaza analogues of phenothiazine". . p. 117 - 120. Retrieved 2007/10/02.