Technology Process of 6-broMo-1-Methyl-1H-pyrrolo[3,2-b]pyridine6-broMo-1-Methyl-1H-pyrrolo[3,2-b]pyridine
There total 4 articles about 6-broMo-1-Methyl-1H-pyrrolo[3,2-b]pyridine6-broMo-1-Methyl-1H-pyrrolo[3,2-b]pyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6-bromo-1H-pyrrolo[3,2-b]pyrridine;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
for 1h;
Cooling with ice;
methyl iodide;
In
N,N-dimethyl-formamide; mineral oil;
at 25 ℃;
for 2h;
- Guidance literature:
-
6-bromo-1H-pyrrolo[3,2-b]pyrridine; carbonic acid dimethyl ester;
With
tetrabutylammomium bromide; triethylamine;
In
ethyl acetate; N,N-dimethyl-formamide;
at 25 - 87 ℃;
for 20h;
Large scale;
In
tert-butyl methyl ether; water;
at 25 ℃;
for 0.5h;
Large scale;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N,N-dimethyl-formamide / 7.5 h / 20 - 90 °C / Large scale
2.1: iron(III) chloride; pyrographite; hydrazine hydrate / isopropyl alcohol / 22 h / 30 - 80 °C / Large scale
3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C
3.2: 0.5 h / 0 - 25 °C
With
iron(III) chloride; sodium hydride; pyrographite; hydrazine hydrate;
In
N,N-dimethyl-formamide; isopropyl alcohol;