2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid

Base Information

• Chemical Name: 2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid
• CAS No.: 739364-95-5
• Molecular Formula: C8H7N3O2
• Molecular Weight: 177.162
• Hs Code.: 2933990090
• Mol file: 739364-95-5.mol

Synonyms:2-Methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid;QC-3758;SC1102;

Chemical Property of 2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid

Chemical Property:

• Melting Point: 238 °C(dec.)
• PKA: -0.17±0.41(Predicted)
• PSA: 67.49000
• Density: 1.49±0.1 g/cm3 (20 oC 760 Torr)
• LogP: 0.73590
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

99% ^*data from raw suppliers

2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic Acid is a reactant used in the preparation of DPP-IV inhibitors.

Technology Process of 2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid

There total 3 articles about 2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.4%

2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid ethyl ester (1263061-14-8) → 2-methylpyrazolo[1,5-a] pyrimidine-6-carboxylic acid (739364-95-5)

Guidance literature:

With water; sodium hydroxide; at 60 ℃; Large scale;

Reference yield: 76.7%

2-methylpyrazolo[1,5-a]pyrimidine-6-carbaldehyde (933692-37-6) → 2-methylpyrazolo[1,5-a] pyrimidine-6-carboxylic acid (739364-95-5)

Guidance literature:

With sodium chlorite; dihydrogen peroxide; In water; at 50 ℃; for 1h; Reagent/catalyst; Temperature; Solvent;

Reference yield: 63.0%

2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid amide (338953-49-4) → 2-methylpyrazolo[1,5-a] pyrimidine-6-carboxylic acid (739364-95-5)

Guidance literature:

With sodium hydroxide; In ethanol; at 70 ℃; for 1h;

upstream raw materials:

2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid amide

2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid ethyl ester

2-methylpyrazolo[1,5-a]pyrimidine-6-carbaldehyde

Downstream raw materials:

N-[2-({2-[(2S)-2-cyanopyrrolidine-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide hydrochloride

(S)-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid {2-[(2-cyanopyrrolidin-1-yl)-2-oxoethylamino]-2-methylpropyl}amide