Technology Process of 2-Azaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester
There total 6 articles about 2-Azaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
tetrahydrofuran;
at 20 ℃;
for 5h;
pH=9 - 10;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-dodecylthiol / N,N-dimethyl-formamide / 2.5 h / 20 °C
2: sodium hydroxide / tetrahydrofuran / 5 h / 20 °C / pH 9 - 10
With
1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; 1-dodecylthiol;
In
tetrahydrofuran; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: thionyl chloride / 3 h / 0 - 80 °C / Inert atmosphere
2: lithium aluminium tetrahydride / diethyl ether / 0.5 h / 0 - 20 °C
3: triethylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere
4: potassium carbonate / dimethyl sulfoxide / 8 h / 75 °C / Inert atmosphere
5: 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-dodecylthiol / N,N-dimethyl-formamide / 2.5 h / 20 °C
6: sodium hydroxide / tetrahydrofuran / 5 h / 20 °C / pH 9 - 10
With
lithium aluminium tetrahydride; thionyl chloride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium hydroxide; 1-dodecylthiol;
In
tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
