665-04-3

Basic information

• Product Name: 2-azaspiro[3.3]heptane
• Synonyms: 2-azaspiro[3.3]heptane;2-azaspiro[3.3]heptane oxalate;2-Azaspiro[3.3]heptane-HCl;2-Azaspiro[3.3]heptane hydrochloride
• CAS NO: 665-04-3
• Molecular Formula: C₆H₁₁N
• Molecular Weight: 97.16
• Mol File: 665-04-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 140-142℃
• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2-azaspiro[3.3]heptane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-azaspiro[3.3]heptane(665-04-3)
• EPA Substance Registry System: 2-azaspiro[3.3]heptane(665-04-3)

Safety Data

• Hazardous Substances Data: 665-04-3(Hazardous Substances Data)

Usage

General Description

2-azaspiro[3.3]heptane, also known as azetidine, is a heterocyclic compound that contains a four-membered ring with a nitrogen atom. It is used in the synthesis of various pharmaceuticals, including antipsychotic drugs such as clozapine and olanzapine. This chemical is also used in the production of other organic compounds, such as agrochemicals and fine chemicals. 2-azaspiro[3.3]heptane has a unique molecular structure that makes it valuable in the field of medicinal chemistry, and its versatility in synthesis has led to its use in various applications in the pharmaceutical and chemical industries.

Upstream product

• 743438-40-6 N-(1-chloromethyl-cyclobutylmethyl)-4-methyl-benzenesulfonamide 
• 91-20-3 naphthalene 
• 64936-58-9 cyclobutane-1,1-diylbis(methylene)dimethanesulfonate 
• 3779-29-1 diethyl cyclobutane-1,1-dicarboxylate 
• 2041-56-7 [1-(aminomethyl)cyclobutyl]methanol 
• 5445-51-2 cyclobutane-1,1'-dicarboxylic acid 
• 4415-73-0 [1-(hydroxymethyl)cyclobutyl]methanol 

Downstream Products

• 1259489-92-3 N-Boc-2-azaspiro[3,3]heptane 
• 743438-38-2 2-(2-aza-spiro[3.3]hept-2-yl)-ethanol 

Relevant articles and documents

Method for mildly preparing 2-azaspiro [3.3] heptane hydrochloride

The invention relates to a method for mildly preparing 2-azaspiro [3.3] heptane hydrochloride, and solves the technical problem that in historical literatures, harsh conditions of strong base sodium are needed. The synthesis method comprises the following steps: (1) reducing cyclobutane-1,1-dicarboxylic acid into dimethyl alcohol; (2) reacting the 1, 1-cyclobutane dimethyl carbinol with methanesulfonyl chloride to generate 1,1-cyclobutane dimethyl carbinol dimethyl sulfonate; (3) carrying out ring closing on the 1,1-cyclobutane dimethyl carbinol dimethyl sulfonate and the 2-nitrobenzene sulfonamide to generate 2-(2-nitrobenzenesulfonyl)-2-azaspiro [3.3] heptane; (4) enabling the 2-(2-nitrobenzenesulfonyl)-2-azaspiro [3.3] heptane to react with dodecanethiol under the action of DBU to remove the 2-nitrobenzenesulfonyl so as to generate 2-azaspiro [3.3] heptane; and (5) reacting the 2-azaspiro [3.3] heptane with BOC anhydride to generate Boc-2-azaspiro [3.3] heptane, and then performing treatment with hydrochloric acid to obtain the 2-azaspiro [3.3] heptane hydrochloride. The method is mild and easy to operate, and avoids violent conditions of removing amino protecting groups by strong base at high temperature.

QUINAZOLINE DERIVATIVE AS TYROSINE-KINASE INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

The invention relates to a quinazoline derivative represented by the general formula (I), a pharmaceutical acceptable salt and a stereoisomer thereof as tyrosine kinase inhibitor, wherein R1, R2, R3, R3', R