665-04-3

Usage

Uses

Used in Pharmaceutical Industry:
2-azaspiro[3.3]heptane is used as a key intermediate in the synthesis of antipsychotic drugs such as clozapine and olanzapine. Its molecular structure plays a crucial role in the development of these medications, contributing to their therapeutic effects.
Used in Chemical Industry:
2-azaspiro[3.3]heptane is also utilized in the production of other organic compounds, including agrochemicals and fine chemicals. Its presence in these industries highlights its broad applicability and the diversity of its chemical properties, which are harnessed for various purposes beyond medicinal applications.

Upstream product

• 743438-40-6 N-(1-chloromethyl-cyclobutylmethyl)-4-methyl-benzenesulfonamide 
• 2041-56-7 [1-(aminomethyl)cyclobutyl]methanol 
• 91-20-3 naphthalene 
• 4415-73-0 [1-(hydroxymethyl)cyclobutyl]methanol 
• 5445-51-2 cyclobutane-1,1'-dicarboxylic acid 
• 3779-29-1 diethyl cyclobutane-1,1-dicarboxylate 
• 64936-58-9 cyclobutane-1,1-diylbis(methylene)dimethanesulfonate 

Downstream Products

• 1259489-92-3 N-Boc-2-azaspiro[3,3]heptane 
• 743438-38-2 2-(2-aza-spiro[3.3]hept-2-yl)-ethanol 

Relevant academic research and scientific papers

Method for mildly preparing 2-azaspiro [3.3] heptane hydrochloride

The invention relates to a method for mildly preparing 2-azaspiro [3.3] heptane hydrochloride, and solves the technical problem that in historical literatures, harsh conditions of strong base sodium are needed. The synthesis method comprises the following steps: (1) reducing cyclobutane-1,1-dicarboxylic acid into dimethyl alcohol; (2) reacting the 1, 1-cyclobutane dimethyl carbinol with methanesulfonyl chloride to generate 1,1-cyclobutane dimethyl carbinol dimethyl sulfonate; (3) carrying out ring closing on the 1,1-cyclobutane dimethyl carbinol dimethyl sulfonate and the 2-nitrobenzene sulfonamide to generate 2-(2-nitrobenzenesulfonyl)-2-azaspiro [3.3] heptane; (4) enabling the 2-(2-nitrobenzenesulfonyl)-2-azaspiro [3.3] heptane to react with dodecanethiol under the action of DBU to remove the 2-nitrobenzenesulfonyl so as to generate 2-azaspiro [3.3] heptane; and (5) reacting the 2-azaspiro [3.3] heptane with BOC anhydride to generate Boc-2-azaspiro [3.3] heptane, and then performing treatment with hydrochloric acid to obtain the 2-azaspiro [3.3] heptane hydrochloride. The method is mild and easy to operate, and avoids violent conditions of removing amino protecting groups by strong base at high temperature.

QUINAZOLINE DERIVATIVE AS TYROSINE-KINASE INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

The invention relates to a quinazoline derivative represented by the general formula (I), a pharmaceutical acceptable salt and a stereoisomer thereof as tyrosine kinase inhibitor, wherein R1, R2, R3, R3', R

QUINAZOLINE DERIVATIVE AS TYROSINE-KINASE INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

The invention relates to a quinazoline derivative represented by the general formula (I), a pharmaceutical acceptable salt and a stereoisomer thereof as tyrosine kinase inhibitor, wherein R1, R2, R3, R3′, R

Estrogen receptor ligands. Part 7: Dihydrobenzoxathiin SERAMs with bicyclic amine side chains

A series of benzoxathiin SERAMs with bicyclic amine side chains was prepared. Minor modifications in the side chain resulted in significant effects on biological activity, especially in uterine tissue.