1-Methyl-3-azetidinecarboxylic acid

Base Information

• Chemical Name: 1-Methyl-3-azetidinecarboxylic acid
• CAS No.: 875629-26-8
• Molecular Formula: C5H9NO2
• Molecular Weight: 115.132
• Hs Code.: 2933998090
• Mol file: 875629-26-8.mol

Synonyms:1-Methyl-3-azetidinecarboxylic acid

Chemical Property of 1-Methyl-3-azetidinecarboxylic acid

Chemical Property:

• Vapor Pressure: 0.0866mmHg at 25°C
• Boiling Point: 208.3°C at 760 mmHg
• PKA: 2.41±0.20(Predicted)
• Flash Point: 79.8°C
• PSA: 40.54000
• Density: 1.221g/cm³
• LogP: -0.42950
• Storage Temp.: 2-8°C

Purity/Quality:

98%, ^*data from raw suppliers

1-Methyl-3-azetidinecarboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Methyl-3-azetidinecarboxylic acid

There total 1 articles about 1-Methyl-3-azetidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3-azetidinecarboxylic acid (36476-78-5) → 1-methylazetidine-3-carboxylic acid (875629-26-8)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; water; under 3000.3 Torr;

Reference yield: 85.0%

1-methylazetidine-3-carboxylic acid (875629-26-8) + 5-phenyl-N-[trans-3-(hydrazinecarbonyl)cyclobutyl]isoxazole-3-carboxamide → 5-phenyl-N-[trans-3-[[(1-methylazetidin-3-yl)formohydrazido]carbonyl]cyclobutyl]isoxazole-3-carboxamide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield: 79.0%

1-methylazetidine-3-carboxylic acid (875629-26-8) + (S)-7-amino-7-(5-(2-fluorophenyl)-1H-imidazol-2-yl)-1-(isoxazol-3-yl)heptan-1-one TFA salt → (S)-N-(1-(4-(2-fluorophenyl)-1H-imidazol-2-yl)-7-(isoxazol-3-yl)-7-oxoheptyl)-1-methylazetidine-3-carboxamide

Guidance literature:

With 4-methyl-morpholine; 1-[(1-(cyano-?2-?ethoxy-?2-?oxoethylidenaminooxy)?dimethylamino-?morpholino)]-uronium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/acsmedchemlett.0c00302

upstream raw materials:

formaldehyd

3-azetidinecarboxylic acid

Refernces