1-methyl-1H-pyrazole-4-carbohydrazide

Base Information

• Chemical Name: 1-methyl-1H-pyrazole-4-carbohydrazide
• CAS No.: 170020-91-4
• Molecular Formula: C5H8N4O
• Molecular Weight: 140.14
• European Community (EC) Number: 826-183-4
• Mol file: 170020-91-4.mol

Synonyms:1-methyl-1H-pyrazole-4-carbohydrazide;170020-91-4;1-methylpyrazole-4-carbohydrazide;1-Methyl-1H-pyrazole-4-carboxylic acid hydrazide;1H-Pyrazole-4-carboxylicacid,1-methyl-,hydrazide(9CI);1H-Pyrazole-4-carboxylic acid, 1-methyl-, hydrazide;SCHEMBL2828757;BBL038668;MFCD04969895;STK312391;AKOS000310266;FS-5853;SB86145;CS-0217603;FT-0748460;EN300-79185;F83081;1-methyl-1 h-pyrazole-4-carboxylic acid hydrazide

Chemical Property of 1-methyl-1H-pyrazole-4-carbohydrazide

Chemical Property:

• PSA: 72.94000
• LogP: 0.11480
• XLogP3: -1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 140.06981089
• Heavy Atom Count: 10
• Complexity: 138

Purity/Quality:

99% ^*data from raw suppliers

1-Methyl-1H-pyrazole-4-carbohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN1C=C(C=N1)C(=O)NN

Technology Process of 1-methyl-1H-pyrazole-4-carbohydrazide

There total 4 articles about 1-methyl-1H-pyrazole-4-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

ethyl 1-methylpyrazole-4-carboxylate (85290-80-8) → 1-methyl-1H-pyrazole-4-carboxylic acid hydrazide (170020-91-4)

Guidance literature:

With hydrazine hydrate; In ethanol; for 6h; Reflux;

DOI:10.14233/ajchem.2016.19795

Reference yield:

methyl ester of 1-methylpyrazole-4-carboxylic acid (5952-93-2) → 1-methyl-1H-pyrazole-4-carboxylic acid hydrazide (170020-91-4)

Guidance literature:

With hydrazine; at 150 ℃; for 0.25h; Microwave irradiation;

DOI:10.1016/j.bmcl.2014.04.081

Reference yield:

1-methyl-1H-pyrazole-4-carboxylic acid (5952-92-1) → 1-methyl-1H-pyrazole-4-carboxylic acid hydrazide (170020-91-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 5 h / Reflux

2: hydrazine hydrate / ethanol / 6 h / Reflux

With sulfuric acid; hydrazine hydrate; In ethanol;

DOI:10.14233/ajchem.2016.19795

upstream raw materials:

methyl ester of 1-methylpyrazole-4-carboxylic acid

ethyl 1-methylpyrazole-4-carboxylate

1-methyl-1H-pyrazole-4-carboxylic acid

Downstream raw materials:

C₁₉H₂₄N₆OS

C₂₀H₂₄N₆OS

Refernces

• 1、 -. "HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS". Paragraph 0668; 0674. . Retrieved 2018/06/12.